EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN KAMBOJA (Plumeria rubra L.) PADA TIKUS PUTIH (Rattus norvegicus)
Journal Title: As-Syifaa Jurnal Farmasi - Year 2018, Vol 10, Issue 1
Abstract
Inflammation is a body protective response against tissue injury which can be characterized by the formation of edema. Frangipani Leaves contain flavanoids, saponins and alkaloids. The flavanoid compound is considered to have a useful effect for healing edema. This research aimed to examine the effects of anti-inflamatory and determined the dose of ethanol extract of the frangipani leaves (Plumeria rubra L.) as an anti-inflammatory in the rat. The test of anti-inflammatory effect was done by using the Rat Hind Paw Edema method in which test animals it used 15 rats divided into 5 groups: groups I (negative control) was given Na.CMC 1% w/v, group II (positive control) was given diclofenac sodium, group III, IV and V were given the ethanol extract of the frangipani leaves successive doses of 166,6mg/kgBW, 222,2 mg/kgBW, and 277,7 mg/kgBW, all groups were orally administered. The tested animals were induced carrageenan 1% w/v in intraplantar 0,5 mL and were meansured their foot edema volume before performed before induction as the intial volume (Vo), after induction, and 1 hour after the administration of the dosage form for 5 hours with the intervals of 1 hours using the pletismometer. The research result data were proccessed statistically using on-wey anova. Based of the data analysis showed that the ethanol extract of the frangipani leaves have the activity as the anti-inflammatory and statistically, the assay extract group showed the result not significantly different (p>0,05) against the diclofenac sodium group and a dose of 277,7mg/kgBW possessed the best activity compared to a dose of 166,6mg/kgBW and 222,2mg/kgBW.
Authors and Affiliations
Safriani Rahman, Aulia Wati, Ema Sukmawati
Keywords
Related Articles
- EP ID EP539977
- DOI -
- Views 76
- Downloads 0
UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT DAUN WUNGU (Graptophyllum pictum (Linn) Griff) DENGAN METODE FRAP (FERRIC REDUCING ANTIOXIDANT POWER)
Wungu’ leaf is a plant known to contain flavonoids as the antioxidant. Thisresearch aimed to determine the antioxidant activity ethyl acetace fraction of ‘Wungu’ leaf (Graptophyllum pictum (Linn) Griff) by Ferric Reduci...
ANALISIS AKTIVITAS ANTIOKSIDAN SEDIAAN PROPOLIS YANG BEREDAR DI KOTA MAKASSAR DENGAN METODE FRAP (Ferric Reducing Antioxidant Power)
Antioxidants are chemical compounds that can donate one or more electrons to free radical, so that free radicals that can be suppressed.This study aimed to obtain and provide scientific evidence to the public regarding t...
PENENTUAN WAKTU OPTIMUM PRODUKSI METABOLIT SEKUNDER ISOLAT BAKTERI Actinomycetes DARI TANAH RHIZOSFER AKAR TANAMAN JARAK PAGAR (Jatropha curcas L) TERHADAP BAKTERI PATOGEN
The study of optimum time determination of secondary metabolite production of Actinomycetes bacteria isolate from Jatropha curcas L root of the soil (Jatropha curcas (L) of pathogenic bacteria has been done with the aim...
IDENTIFIKASI PENGGUNAAN OBAT PADA PASIEN HIPERTENSI USIA LANJUT DENGAN BEER’S CRITERIA DI INSTALASI RAWAT INAP RUMAH SAKIT IBNU SINA MAKASSAR PERIODE TAHUN 2012
Identification in the use medicine in geriatric patient of hypertension with Beer's Criteria In inpatient installation of Ibnu Sina Makassar hospital period 2012. In this study aims to observe and report on the use of dr...
IDENTIFIKASI DNA Leptospira sp PADA SAMPEL AIR DAN TANAH DI KOTA MAKASSAR
Leptospirosis is a zoonotic disease that can be found all over the world, caused by a pathogenic leptospira genus. This study aims to identify the presence of Leptospira bacterial DNA in water and soil at several locatio...