Effect of 1,5-Bis (3,5-dimethylpyrazol-1-yl)-3-oxapentane Diacetatocopper on Kidney and Spleen of Rats: Histological and Immunohistochemical Evaluation
Journal Title: Asian Journal of Biology - Year 2017, Vol 3, Issue 4
Abstract
The present work was carried out to evaluate the histological and immunohistochemical changes of the kidney and spleen of rats after repeated exposure to 1,5-Bis (3,5-dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper (BDO). Two groups of male albino rats were used. The first group is the control and the second group was i.p. given 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper (12 mg / kg body weight) daily for 6 weeks. The results showed that the administration of BDO to rats exhibits various histological effects on tissues of kidney and spleen. Kidney from treated animals showed congestion of blood vessels, degeneration of renal tubules and glomeruli. The spleen tissue lost its characteristic structure and showing interference \ overlap between red and white pulp, enlarged trabecula and degenerated lymphocytes. Histochemical results revealed depletion of total proteins contents in renal tubules and glomeruli and spleen cells of treated rats. Expression of Bcl-2 protein was increased in the kidney and spleen of treated rats. It is concluded from the present work that BDO induced histopathological alterations and apoptosis in kidney and spleen of rats.
Authors and Affiliations
Amany E. Nofal, Rania A. Ahmed, Ferial A. El-Massady
Keywords
Related Articles
- EP ID EP337839
- DOI 10.9734/AJOB/2017/35256
- Views 51
- Downloads 0
Flora and Fauna Diversity Status on Trans Sumatra Railway Project Development Plan through the Region Sigli – Bireun - Lhokseumawe – Langsa – Besitang, Indonesia
Background and Objectives: Plans to build and operate a trans-urban railway line through Aceh and northern Sumatra between Sigli - Bireun - Lhokseumawe - Langsa - Besitang, allowing impacts on flora and fauna habitat con...
Effects of Palm Oil Mill Effluent on Soil Microflora and Fertility in Calabar – Nigeria
In the present study, an agricultural soil artificially amended with different concentrations of palm oil mill effluent was analysed to determine its impact on the soil microflora and other properties such as pH, organic...
Histological Studies on Heteracris littoralis (Rambur) Treated with Silica Nano-particles / Challenger Formulation
Aim: Local diatomaceous earth (Silica nano-particles) and commercial pesticide (Challenger 36% SC) formulation was tested against alfalfa grasshopper, Heteracris littoralis (Rambur, 1838) (Orthopetra: Acrididae) under la...
Insect Species Diversity and Abundance in and around Federal University of Agriculture, Makurdi Forestry Nursery, Benue State, Nigeria
With the rapid increase in human population, there has been concomitant increase in anthropogenic activities helping to rise to habitat modification. The change in habitat composition and seasonal variations affect the p...
Prevalence of Parasites Infection of Resident Fish Species in a Tropical Reservoir
This study detected, identified and determined the incidence of parasites present in and on Clarias gariepinus, Sarotherodon galilaeus, Oreochromis niloticus and Tilapia zillii in Ero reservoir, a tropical reservoir situ...