Effect of 5-HT deplete on ethanol induced anxiolysis in EPM test
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Based onthe anxiolytic effects of p-CPA were revealed in the most used animal behavior models Moreover, depletion of 5-HT induced by p-CPA or 5, 6-dihydroxytryptamine a neurotoxin destroying serotonergic neurons.Anxiolytic and stimulant effectsof ethanol have been related to the serotonergic system.Therefore, present investigationdetermine the effect of ethanol in serotonin depleted condition on anxiety, separate groups of rats were administered with p-CPA (300 mg/kg, i.p.) for 3 days and 4th day challenged with saline (10 ml/kg, i.p.) or ethanol (1g/kg, i.p.) 30 min thereafter subjected to EPM test and anxiety related indices were measured for 5 min.The administration of p-CPA is effective in the reduction of anxiety through depletion of serotonin and the data of the present study showed thepotentiation of the open arm activity with sub-anxiolytic dose of ethanol (1 g/kg, i.p.) by p-CPA. Therefore, increase in 5-HT transmission might counter regulate ethanol induced traits on anxiety and reduction in 5-HT transmission might enhance these effects on EPM. -
Authors and Affiliations
HinaD. Mehta, Dr. N. Dighade1, S. Mangrulkar3
Keywords
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