Effect of Acute and Chronic Administration of Nicorandil (A Potassium Channel Activator) on Blood Glucose of Albino Rabbit
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 5
Abstract
Many cells are equipped with so called potassium (K+) channels which have an important role in maintaining transmembrane potential. Nicorandil being a K+ channel activator (primary mechanism) causes hyperpolarization of membrane potential of vascular endothelial cells leading to vasodilation. Earlier studies suggest that besides vasodilation this drug could alter physiological blood glucose homeostasis. The purpose of the present study is to evaluate the acute and chronic effect of Nicorandil (graded doses) on fasting and postprandial blood glucose level in albino rabbits (n=30). For this study, the blood glucose levels were estimated before and after intraperitoneal (IP) administration of nicorandil to see its effect. In our study, we observed no significant changes in blood glucose level in acute administration (single dose) even at higher doses 512 mcg/kg body weight (p > 0.1). Although we observed no significant changes in fasting glucose levels, there was significant rise in postprandial levels during chronic administration (for 15 days) p < 0.05.
Authors and Affiliations
Sanjib Das
Keywords
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