Effect of Acute and Chronic Administration of Nicorandil (A Potassium Channel Activator) on Blood Glucose of Albino Rabbit
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 5
Abstract
Many cells are equipped with so called potassium (K+) channels which have an important role in maintaining transmembrane potential. Nicorandil being a K+ channel activator (primary mechanism) causes hyperpolarization of membrane potential of vascular endothelial cells leading to vasodilation. Earlier studies suggest that besides vasodilation this drug could alter physiological blood glucose homeostasis. The purpose of the present study is to evaluate the acute and chronic effect of Nicorandil (graded doses) on fasting and postprandial blood glucose level in albino rabbits (n=30). For this study, the blood glucose levels were estimated before and after intraperitoneal (IP) administration of nicorandil to see its effect. In our study, we observed no significant changes in blood glucose level in acute administration (single dose) even at higher doses 512 mcg/kg body weight (p > 0.1). Although we observed no significant changes in fasting glucose levels, there was significant rise in postprandial levels during chronic administration (for 15 days) p < 0.05.
Authors and Affiliations
Sanjib Das
Keywords
Related Articles
- EP ID EP369758
- DOI -
- Views 90
- Downloads 0
Study of Thyroid Function in Patients with Chronic Kidney Disease
Background: Thyroid dysfunction is a commonly seen endocrine abnormality among CKD patients. CKD has been known to affect the pituitary-thyroid axis and peripheral metabolism of thyroid hormones. This study was conducted...
Enhancing Self- Management in Diabetes: The Value of Therapeutic Education
Diabetes is among the most common, serious and costly chronic diseases and a major cause of morbidity and mortality. Patient education is accepted as a valid component of chronic disease management for patients with chro...
A Comparative Cross-sectional Study on Knowledge Regarding Exclusive Breast Feeding Among Antenatal Mothers Attending Primary and Tertiary Care Centers of Osmania Medical College
Introduction: Exclusive Breast Feeding (EBF) defined by World Health Organization(WHO) as practice of feeding only breast milk (including expressed breast milk) and allows the baby to receive vitamins, minerals or medici...
A Study of Effect of Time Spent on Exercise upon Illness Frequency
Being physically fit plays an important role in human’s life. Physical fitness can be achieved by exercise and healthy diet. This paper provides analysis of time spent on exercise and yearly illness frequency of people i...
Human Milk’s Microbial Population Behavior In Vivo and Ex Vivo
The mobility of human milk microbial community the Armenian women has been studied in vivo and ex vivo. Human milk temporary microbes’ quantity was varied within stages of lactation. Culture based investigations revealed...