Effect of adding clonidine versus fentanyl to intrathecal bupivacaine on spinal block characteristics in orthopedic procedures: A double blind controlled study
Journal Title: International Journal of Medical Science and Public Health - Year 2015, Vol 4, Issue 4
Abstract
Background: Various adjuvants have been used in spinal anesthesia to avoid intraoperative visceral and somatic pain and prolonged postoperative analgesia. Clonidine, partially selective α 2 -agonist drug, is now being used as a neuraxial adjuvant. Objective: To compare the duration and quality of analgesia of clonidine and fentanyl used as adjuvants to intrathecal bupivacaine. Materials and Methods: American Society of Anesthesiologist grade 1 and 2 patients (90 patients) were randomly divided into three groups of 30 patients each for lower limb orthopedic surgeries. Group A received intrathecal 15 mg hyperbaric bupivacaine and 1 ml normal saline, group B received 15 mg hyperbaric bupivacaine and 1 ml (50 μg) fentanyl, and group C received 15 mg hyperbaric bupivacaine and 1 ml (150 μg) clonidine. The onset and duration of sensory and motor block, quality of analgesia, and the incidence of side effects in three groups were observed and compared. Results: Three groups were compared based on the demographic data, and the onset of sensory block at T 8 level and of motor block was compared among these groups. Significant prolongation of duration of sensory ( P = 0.0000001) and motor block ( P = 0.0000001) was found in group C. Significant hypotension was found in group C ( P < 0.05) and the postoperative pain scoring chart (VAS chart) was 1.07 ± 0.87 in group C and 3.27 ± 0.67 in group B ( P < 0.05). Conclusion: Intrathecal clonidine is associated with prolonged motor and sensory block, hemodynamic stability, and low postoperative pain score compared to fentanyl.
Authors and Affiliations
Yogesh Tilkar, Sangeeta Agarwal Bansal, Gauri Shankar Agnihotri
Keywords
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- EP ID EP132862
- DOI http://dx.doi.org/10.5455/ijmsph.2015.2211201494
- Views 57
- Downloads 0
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