EFFECT OF ADDING DEXMEDETOMIDINE VERSUS FENTANYL TO INTRATHECAL BUPIVACAINE ON SPINAL BLOCK CHARACTERISTICS IN GYNAECOLOGICAL PROCEDURESA COHORT STUDY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 32
Abstract
BACKGROUND Various adjuvants have been used along with local anaesthetics to prolong analgesia and to avoid intraoperative pain. Dexmedetomidine, a new highly selective α-2 agonist drug is now being used as a neuraxial adjuvant. The aim of the study was to compare the duration of analgesia and haemodynamic effects of dexmedetomidine or fentanyl given intrathecally with 0.5% hyperbaric bupivacaine. MATERIALS AND METHODS 60 patients classified in ASA class I and II scheduled for gynaecological procedures was studied and they were given 15 mg of hyperbaric bupivacaine (3 cc, 0.5%) plus 5 g dexmedetomidine (in 0.5 mL sterile water Group A) or 15 mg hyperbaric bupivacaine (3 cc, 0.5%) plus 25 g fentanyl (0.5 mL sterile water) Group B intrathecally. RESULTS The result of our study showed that patients in group A had significantly longer duration of analgesia compared to fentanyl group B. The mean duration of analgesia were 375.5 ± 9.19 min. and 256.87 ± 9.72 mins. (P<0.001). The haemodynamic profile was significantly better in fentanyl group B than in dexmedetomidine group A in the first 20-30 mins. after giving the block. CONCLUSION Intrathecal Dexmedetomidine has a longer duration of analgesia when compared to intrathecal Fentanyl. But the hemodynamic profile is better for Fentanyl in the initial period of block when compared to Dexmedetomidine.
Authors and Affiliations
Dhanya R, Nikhil Nandan, Linnette J. Morris
Keywords
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- EP ID EP218691
- DOI 10.18410/jebmh/2017/376
- Views 78
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