Effect of Allopregnenalone (AP) and 4′- Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats
Journal Title: Journal of Medical and Allied Sciences - Year 2014, Vol 4, Issue 1
Abstract
Neurosteroids (NS) are considered important modulators of brain functions. Lindane a pesticide has been shown to affect the nervous system adversely. The present study was designed to explore the modulation of the effects of lindane on convulsions by Allopregnenalone (AP), and 4′-Chlorodiazepam (4′-CD), in both acute and chronic seizure models using Pentylenetetrazole (PTZ). We used acute and chronic models. In the acute model, seizures were induced by PTZ 90mg/kg, intra-peritoneal (i.p.) injection, while in the chronic model, kindling was induced by injecting PTZ 30 mg/kg sub-cutaneous(s.c) on alternate days three times in a week. Lindane produced augmented effect on convulsions by decreasing the onset of preclonic convulsions and increased duration of clonic convulsions. AP (2.5mg/kg, i.p) and 4′-CD (0.5mg/kg, i.p) were able to attenuate the effect of acute as well as chronic exposure of lindane. They significantly increased the onset and decreased the duration of convulsions in lindane-treated rats. These results conclusively demonstrate the efficacy of the neurosteroids in lindane-induced convulsions in both acute as well as chronic models. Thus NS have a potential role as anticonvulsant in treatment of convulsions produced by pesticides like lindane.
Authors and Affiliations
Krishna Tanwar| Department of Pharmacology, Deccan College of Medical Sciences, Hyderabad-500058, Andhra Pradesh, India, Pramod K Mediratta| Department of Pharmacology, University College of Medical Sciences, Dilshad Garden, Delhi-110095, India, Krishna K Sharma| Department of Pharmacology, University College of Medical Sciences, Dilshad Garden, Delhi-110095, India
Keywords
Related Articles
- EP ID EP12702
- DOI -
- Views 403
- Downloads 22
Molecular evolution of pathogenic bacteria based on rrsA gene
Evolution of pathogens in prokaryotic bacteria was studied by 16srRNA genes. In this study rrsA genes of 45 bacteria were considered, which includes pathogens, non-pathogens and out- group bacteria. We considered non-p...
Uncommon presentation of common clinical case
Lipoma is the most common benign tumor of the mesenchyme. Common location being trunk and limbs. Lipoma can occur rarely in the head and neck region with most common location being the posterior neck. We report a case...
Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance
The objective of this study was to isolate pathogenic bacteria in neonatal septicaemia cases, and to know their antibiograms. Under aseptic precautions, blood was drawn from 140 neonates with suspected septicaemia and i...
Diabetes mellitus the ‘Silent Killer’ of mankind: An overview on the eve of upcoming World Health Day!
The impact of social media on the academic performance of second year medical students at College of Medicine, University of Babylon, Iraq
Social media applications and their use among students have witnessed dramatic increase in the last decade and data on their effect on students academic performance are inconsistent. The aim of this study was to assess...