Effect of Allopregnenalone (AP) and 4′- Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats
Journal Title: Journal of Medical and Allied Sciences - Year 2014, Vol 4, Issue 1
Abstract
Neurosteroids (NS) are considered important modulators of brain functions. Lindane a pesticide has been shown to affect the nervous system adversely. The present study was designed to explore the modulation of the effects of lindane on convulsions by Allopregnenalone (AP), and 4′-Chlorodiazepam (4′-CD), in both acute and chronic seizure models using Pentylenetetrazole (PTZ). We used acute and chronic models. In the acute model, seizures were induced by PTZ 90mg/kg, intra-peritoneal (i.p.) injection, while in the chronic model, kindling was induced by injecting PTZ 30 mg/kg sub-cutaneous(s.c) on alternate days three times in a week. Lindane produced augmented effect on convulsions by decreasing the onset of preclonic convulsions and increased duration of clonic convulsions. AP (2.5mg/kg, i.p) and 4′-CD (0.5mg/kg, i.p) were able to attenuate the effect of acute as well as chronic exposure of lindane. They significantly increased the onset and decreased the duration of convulsions in lindane-treated rats. These results conclusively demonstrate the efficacy of the neurosteroids in lindane-induced convulsions in both acute as well as chronic models. Thus NS have a potential role as anticonvulsant in treatment of convulsions produced by pesticides like lindane.
Authors and Affiliations
Krishna Tanwar| Department of Pharmacology, Deccan College of Medical Sciences, Hyderabad-500058, Andhra Pradesh, India, Pramod K Mediratta| Department of Pharmacology, University College of Medical Sciences, Dilshad Garden, Delhi-110095, India, Krishna K Sharma| Department of Pharmacology, University College of Medical Sciences, Dilshad Garden, Delhi-110095, India
Keywords
Related Articles
- EP ID EP12702
- DOI -
- Views 377
- Downloads 22
A rare case of ischemic stroke
The artery of Percheron is a rare vascular entity of cerebral circulation. High degree of suspicion is required to diagnose this condition. Artery of Percheron infarction should be considered in all patients presenting...
Diabetes mellitus the ‘Silent Killer’ of mankind: An overview on the eve of upcoming World Health Day!
Awareness of substance use and its associated factors in young Saudi students
Adolescence is the stage that carries the greatest risk for initiating substance use as it is a transitional stage of physical and mental human development. Studies in younger populations have demonstrated a positive a...
Free radicals, oxidative stress and importance of antioxidants in human health
Reactive oxygen species (ROS) is a collective term used for oxygen containing free radicals, depending on their reactivity and oxidizing ability. ROS participate in a variety of chemical reactions with biomolecules lea...
A rare cause of internal herniation - Intermesocolic fossa of Brosike
Internal Hernias are defined as “The protrusion of viscera through a normal or abnormal opening within the boundaries of the peritoneal cavity†which account for 0.5 – 5.8% of small bowel obstructions while Autops...