Effect of Allopregnenalone (AP) and 4′- Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats
Journal Title: Journal of Medical and Allied Sciences - Year 2014, Vol 4, Issue 1
Abstract
Neurosteroids (NS) are considered important modulators of brain functions. Lindane a pesticide has been shown to affect the nervous system adversely. The present study was designed to explore the modulation of the effects of lindane on convulsions by Allopregnenalone (AP), and 4′-Chlorodiazepam (4′-CD), in both acute and chronic seizure models using Pentylenetetrazole (PTZ). We used acute and chronic models. In the acute model, seizures were induced by PTZ 90mg/kg, intra-peritoneal (i.p.) injection, while in the chronic model, kindling was induced by injecting PTZ 30 mg/kg sub-cutaneous(s.c) on alternate days three times in a week. Lindane produced augmented effect on convulsions by decreasing the onset of preclonic convulsions and increased duration of clonic convulsions. AP (2.5mg/kg, i.p) and 4′-CD (0.5mg/kg, i.p) were able to attenuate the effect of acute as well as chronic exposure of lindane. They significantly increased the onset and decreased the duration of convulsions in lindane-treated rats. These results conclusively demonstrate the efficacy of the neurosteroids in lindane-induced convulsions in both acute as well as chronic models. Thus NS have a potential role as anticonvulsant in treatment of convulsions produced by pesticides like lindane.
Authors and Affiliations
Krishna Tanwar| Department of Pharmacology, Deccan College of Medical Sciences, Hyderabad-500058, Andhra Pradesh, India, Pramod K Mediratta| Department of Pharmacology, University College of Medical Sciences, Dilshad Garden, Delhi-110095, India, Krishna K Sharma| Department of Pharmacology, University College of Medical Sciences, Dilshad Garden, Delhi-110095, India
Keywords
Related Articles
- EP ID EP12702
- DOI -
- Views 383
- Downloads 22
A comparative study between propofol and thiopentone for hemodynamic parameters during induction of general anesthesia in surgical patients
Hemodynamic stability is very much important during induction of general anesthesia. So, this study was planned to compare hemodynamic parameters during induction by thiopentone and propofol. This prospective study was...
A rare case of multiple intussusceptions in Peutz–Jeghers syndrome
Peutz–Jeghers syndrome is a rare autosomal dominant genetic disorder characterized by the development of benign hamartomatous polyps in the gastrointestinal tract and hyperpigmented macules on the lips and oral mucosa...
Noughts and crosses: The uncertain future of TB control in India
Role of imaging in the evaluation of a large left atrial myxoma: A case report and review of literature
Cardiac myxomas of giant size are rare. Their clinical presentation depends on the rapidity of growth of the mass and pressure effects which it produces. Echocardiography alone is sufficient in most cases for initial d...
Clinical and histopathological study of primary cutaneous macular amyloidosis
Primary cutaneous amyloidosis often presents with pigmentary dystonias of the skin in the form of asymptomatic reticulate hyperpigmentation or pruritic lichenoid papular lesions. The aim of this study was to evaluate t...