Effect of alpha-lipoic acid on asymmetric dimethylarginine and disability in multiple sclerosis patients: A randomized clinical trial
Journal Title: Electronic Physician - Year 2017, Vol 9, Issue 7
Abstract
BACKGROUND: Multiple Sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system. Oxidative stress plays a major role in the onset and progression of MS. Asymmetric dimethylarginine (ADMA) formation is dependent on oxidative stress status. OBJECTIVE: We examined whether alpha-lipoic acid (ALA) as a potent antioxidant could improve the Expanded Disability Status Scale (EDSS) and decrease plasma level of ADMA in multiple sclerosis patients. METHODS: In a randomized, double-blinded clinical trial conducted at Sina Hospital in Tehran, Iran, from September 2009 to July 2011, 24 patients with relapsing-remitting MS were divided into a treatment group receiving ALA (1200mg/day) for 12 weeks and a control group receiving placebo. Then patients' EDSS and Plasma levels of ADMA were measured at baseline and 12 weeks later. Statistical analysis was done by SPSS software version 16 using the K-S test, Chi square, Mann-Whitney U-test and Wilcoxon test. RESULTS: The plasma levels of ADMA in the intervention group were decreased significantly (p=0.04). Also, no patient had increased EDSS score in the supplement group, where 2 out of 12 patients in the placebo group experienced so. Comparing the serum level of ADMA between the two groups failed to show any significant change in the supplement group compared with the control group. CONCLUSION: Considering that ADMA is produced by oxidative stress in MS patients and leads to increase of inflammation, ALA may have the potential of beneficial effects in them, in part, by decreasing the plasma level of ADMA and stopping progression. TRIAL REGISTRATION: The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the Irct ID: No. IRCT138812222602N2. FUNDING: The authors received no financial support for the research, authorship, and/or publication of this article
Authors and Affiliations
Mohammad Khalili, Madjid Soltani, Shirin Amiri Moghadam, Parvin Dehghan, Amirreza Azimi, Omid Abbaszadeh
Keywords
Related Articles
- EP ID EP323666
- DOI 10.19082/4899
- Views 95
- Downloads 0
Meanings of Health for Iranian Diabetic Patients: A qualitative study
INTRODUCTION: Health is an exclusive and subjective phenomenon, and one of the most important situations with regard to perception of health, arises when patients suffer from a chronic disease. This study was conducted w...
E-Health literacy of medical and health sciences university students in Mashhad, Iran in 2016: a pilot study
BACKGROUND: In order to provide a better healthcare education to the society, health care students should have an acceptable electronic health (E-Health) literacy. OBJECTIVE: The aim of this study was to assess the leve...
Exploring the experiences of Iranian adolescent mothers about the maternal role: a qualitative study
BACKGROUND: Early motherhood is one of the most important issues in developing countries. Adolescent mothers are not sufficiently prepared to accept the maternal role. How to achieve success in the maternal role should b...
Organizational Climate and Work Addiction in Shahid Sadoughi University of Medical Sciences, 2014: a Case Study.
The occupational nature of employees in headquarters units of the University requires them to deal with support issues. Thus, there is some pressure on these employees to complete their assignments on time so that employ...
Effectiveness of teaching cognitive-behavioral techniques on locus of control in hemodialysis patients
BACKGROUND: Many of the cognitive behavioral models and therapeutic protocols developed so far for psychological disorders and chronic diseases have proved effective through clinical research. OBJECTIVE: This study aime...