Effect of Alpha-Tocopherol on Lipoprotein Profile in Normal and Hyperlipidaemic Rats
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Atherosclerosis is the underlying cause of coronary artery disease, which in turn results from raised oxidized lipoprotein levels. This study was aimed to find out the effect of an anti-oxidant, Alpha-tocopherol, on serum lipoprotein level in rats. Alpha-tocophopherol was administered orally daily in a dose 60mg/kg body weight for 90 days to groups of control and hyperlipidemic rats, and the serum lipoprotein levels (total cholesterol, triglyceride, LDL, HDL, VLDL) were measured on 0, 30, 60 and 90 days of drug administration and compared. The results showed that Alpha-tocopherol in a dose of 6mg/100gm body weight daily orally for 90 days prevented serum lipid parameters to shift in favour of atherosclerosis, both in normal and hyperlipidemic rats.Hence, Alpha-tocopherol has significant hypolipidemic activity in animal model.
Authors and Affiliations
Dr. Sachchidanand Pandey1, Dr. Sabita Mohapatra, Dr. Shanti Kanungo3
Keywords
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- EP ID EP365282
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