Effect of Anti-Cholinergics with Tamsulosin for Treating Benign Prostate Hyperplasia Patients with an Overactive Bladder: A Clinico-Comparative Study
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 5
Abstract
Objective: Overactive bladder (OAB) symptoms are due to detrusor over activity (DOA) which is characterized by involuntary detrusor contractions during bladder flling. It may co-exist with BOO due to benign prostate hyperplasia (BPH) in men. Hence, the study was designed to assess and compare the clinical effcacy of combination therapy of anti-muscarinics with α-blockers versus α-blockers monotherapy in BPH patients with OAB. Methods: This study was carried out in the urology department of a tertiary care hospital for a period of 4 months. Clinical and biochemistry reports of 90 patients were collected in designed case report forms. All statistical analyses were performed using IBM Statistical Package for Social Sciences 17 and Graph Pad Prism 7.0. Results: The perceived change from baseline values was comparatively better in patients who received combination of tamsulosin with tolterodine than other two groups. All the three groups were effective in reducing the symptoms. Conclusion: Tamsulosin with tolterodine at a recommended dosage has shown to be clinically more effective than oxybutynin after 12 weeks of treatment for men with OAB in BPH. Patients with increased urinary retention risk should be carefully monitored during the course of treatment.
Authors and Affiliations
Prabhu Deva T| Department of Pharmacy Practice and Pharm-D, Sri Venkateswara College of Pharmacy, Chittoor, India, Mounika P| Department of Pharmacy Practice and Pharm-D, Sri Venkateswara College of Pharmacy, Chittoor, India, Sai Charan K| Department of Pharmacy Practice and Pharm-D, Sri Venkateswara College of Pharmacy, Chittoor, India, Shabnam S| Department of Pharmacy Practice and Pharm-D, Sri Venkateswara College of Pharmacy, Chittoor, India, Dhivya K| Department of Pharmacy Practice and Pharm-D, Sri Venkateswara College of Pharmacy, Chittoor, India, Corresponding e-mail: divyapharmd@gmail.com
Keywords
Related Articles
- EP ID EP12361
- DOI -
- Views 273
- Downloads 15
CONSOLIDATE EFFECT OF VIBHAGHA PRANAYAMA, NADISHUDDI PRANAYAMA, SAVITHIRI PRANAYAMA AND KAPALABHATI PRANAYAMA ON THE PULMONARY FUNCTIONAL STATUS OF YOUNG HEALTHY MALE SUBJECTS
Introduction: Pranayama is believed to increase the respiratory stamina, relax the chest muscles, expand the lungs, raise energy levels, calm the body and cause over-all improvement in lung functions. In the present st...
HAEMODYNAMIC RESPONSE TO NASOTRACHEAL INTUBATION UNDER GENERAL ANAESTHESIA: COMPARISON BETWEEN FIBEROPTIC BRONCHOSCOPY AND DIRECT LARYNGOSCOPY
Study Objective: To compare haemodynamic response in nasotracheal intubation under general anaesthesia between FOB and DLS as one accomplished with a FOB is thought to attenuate the circulatory responses to intubation...
DIAGNOSTIC DILEMMA IN A CASE OF GINGIVAL LESION PLASMA CELL GRANULOMA VERSUS EXTRAMEDULLARY PLASMACYTOMA- RESOLVED BY IMMUNOHISTOCHEMISTRY: A CASE STUDY
Plasma cell granuloma is a rare reactive tumor- like lesion composed of polyclonal plasma cells. It primarily affects the lungs but occurs in other anatomic locations such as orbit, paranasal sinuses, larynx, tonsils, e...
Evaluation of the effect of distraction in the two groups of inflating the balloon and mother's armson the pain of venipuncture in children aged 3-6
Children get irritable, restless and excited in response to pain. Most children predict the pain induced by injection and prevent it by non-conformist behavior associated with anxiety before injection. They usually spen...
In vitro Anti-Candidal effects of Aqueous and Methanolic Extracts of Walnut (Juglansregia) Tree Fruit Peel in Comparision with Fluconazole
The appearance of fungal species resistant to antifungal drugs among the Candida genus and also their numerous side effects, convince the researchers to work on new therapeutic methods with minimal side effects for huma...