Effect of Anti-Cholinergics with Tamsulosin for Treating Benign Prostate Hyperplasia Patients with an Overactive Bladder: A Clinico-Comparative Study
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 5
Abstract
Objective: Overactive bladder (OAB) symptoms are due to detrusor over activity (DOA) which is characterized by involuntary detrusor contractions during bladder flling. It may co-exist with BOO due to benign prostate hyperplasia (BPH) in men. Hence, the study was designed to assess and compare the clinical effcacy of combination therapy of anti-muscarinics with α-blockers versus α-blockers monotherapy in BPH patients with OAB. Methods: This study was carried out in the urology department of a tertiary care hospital for a period of 4 months. Clinical and biochemistry reports of 90 patients were collected in designed case report forms. All statistical analyses were performed using IBM Statistical Package for Social Sciences 17 and Graph Pad Prism 7.0. Results: The perceived change from baseline values was comparatively better in patients who received combination of tamsulosin with tolterodine than other two groups. All the three groups were effective in reducing the symptoms. Conclusion: Tamsulosin with tolterodine at a recommended dosage has shown to be clinically more effective than oxybutynin after 12 weeks of treatment for men with OAB in BPH. Patients with increased urinary retention risk should be carefully monitored during the course of treatment.
Authors and Affiliations
Prabhu Deva T| Department of Pharmacy Practice and Pharm-D, Sri Venkateswara College of Pharmacy, Chittoor, India, Mounika P| Department of Pharmacy Practice and Pharm-D, Sri Venkateswara College of Pharmacy, Chittoor, India, Sai Charan K| Department of Pharmacy Practice and Pharm-D, Sri Venkateswara College of Pharmacy, Chittoor, India, Shabnam S| Department of Pharmacy Practice and Pharm-D, Sri Venkateswara College of Pharmacy, Chittoor, India, Dhivya K| Department of Pharmacy Practice and Pharm-D, Sri Venkateswara College of Pharmacy, Chittoor, India, Corresponding e-mail: divyapharmd@gmail.com
Keywords
Related Articles
- EP ID EP12361
- DOI -
- Views 317
- Downloads 15
Outcome of Operative Fixation of Midclavicular Fractures by Titanium Elastic Nailing System (TENS) - A Prospective Study in 21 Patients
This study is based on the technique of minimally-invasive osteosynthesis using Titanium elastic nails (TENS) in OTA Type Amidclavicular fractures with displacement or shortening more than 2 cm. The aim of the study was...
Effectiveness of death education program by methods of didactic, experiential, and 8A model on the reduction of death distress among nurses
Death distress includes death anxiety, death depression, and death obsession. There are different approaches to death education program include didactic, experiential, and 8A model. Death distress of nurses can have an...
Anther development and microsporegenesis in Gossypium herbaceum L.
Gosseypium herbaceum L. is known as cotton plant belongs to the family Malvaceae. This plant is widely distributed throughout western India, Africa, Middle East countries, central Asia, and Availability is found in Iran...
IMMEDIATE MOBILISATION WITH COMPLETE WEIGHT BEARING AFTER UNCEMENTED TOTAL HIP REPLACEMENT IN ELDERLY
This prospective study was analyzed in 23 patients who were allowed to do immediate weight bearing after uncemented total hip arthroplasty. Immediate mobilization shortened the hospital stay and facilitated early rehab...
A DESCRIPTIVE STUDY ON PREVALENCE OF BACTERIAL PATHOGENS IN DIABETIC ULCER AND INTERVENTIONAL COMPONENT FOR THE PREVENTION OF FOOT ULCERS
Diabetes is considered to have reached epidemic proportions worldwide. The most distressing complication of diabetes is foot ulcer and is the major cause of lower limb amputation. Hence, they require a prolonged hospita...