Effect of Anti-Inflammatory Eye Drops on Bacterial Keratitis
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 19, Issue 1
Abstract
Aim To evaluate and compare the effect of non-steroidal anti-inflammatory drug (NSAID) eye drop and steroid eye drop on bacterial keratitis patient’s response to antibiotics. Methods From Sep. 2017 to Sep. 2018, 60 patients diagnosed with bacterial keratitis were enrolled. 20 patients who did not want anti-inflammatory eye drop were treated with antibiotics. 20 patients were treated with steroid eye drop and 20 patients were treated with NSAID eye drop. Patients were evaluated for the ulcer size, ulcer location, visual acuity, recurrence rate. Anti-inflammatory treatment was considered when corneal epithelial defect, corneal infiltration and anterior chamber inflammation were decreased after antibiotic eye drops use. In case of re-aggravation, anti-inflammatory treatment was discontinued. ResultsThere was no significant difference in mean age, sex, ulcer size, ulcer location, and initial visual acuity between three groups. All 60 patients diagnosed unilateral bacterial keratitis. After 3-month, anti-inflammatory treatment groups showed significant improvement of best corrected visual acuity (BCVA) compared to the group treated with antibiotics (p=0.045). However, there was no statistically significant difference in the 3-month BCVA between NSAID group and steroid group (P=0.743). In NSAID treated group, one of 20 eyes (5.0%) showed re-aggravating inflammation, while steroid treated group, 3 of 20 eyes (15.0%) showed re-aggravating inflammation. Recurrence rate was lower in NSAID treated group, however, there was no statistically significant difference between two groups (P=0.605). Conclusion In bacterial keratitis, NSAID has an inflammatory control effect like steroid and extra-advantage on lower recurrence rate.
Authors and Affiliations
Hwa-Rang Lim, Jae Woong Koh
Keywords
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- EP ID EP622772
- DOI 10.26717/BJSTR.2019.19.003240
- Views 144
- Downloads 0
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