EFFECT OF ANTI-OXIDANT SUPPLEMENTATION IN VITILIGO PATIENTS DURING NARROW BAND UVB PHOTOTHERAPY
Journal Title: International Journal of Pharmacognosy - Year 2014, Vol 1, Issue 11
Abstract
Vitiligo is an acquired idiopathic epidermal pigment loss occurring on the body. The prevalence of the disease is less than 0.5%. Pathogenesis of vitiligo has been intriguing researchers for decades. Basic defect in vitiligo is the disappearance of melanocytes. Several therapies are prescribed for the disease; the most effective one is narrowband UVB phototherapy. Several evidence-based hypotheses have been proposed to explain the loss of melanocytes in the epidermis. Oxidative stress has been speculated to play a pivotal role in disease pathogenesis. The present study was planned to determine the effect of oral antioxidant supplementation for 4 weeks in patients undergoing Narrow Band UVB phototherapy and comparison with patients receiving Narrow Band UVB phototherapy only. 30 Vitiligo patients were recruited for the study from OPD of Department of Dermatology, Era’s Lucknow Medical College & Hospital, Lucknow. Blood was investigated for anti-oxidant parameters such as Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx) and Lipid peroxides (LPO). After 4 weeks oral anti-oxidant supplementation, we observed significant (p<0.05) increase in CAT, SOD and GPx activity in vitiligo patients receiving anti-oxidant and NB-UVB phototherapy as well as in NB-UVB phototherapy alone receiving group, as compared to baseline values. We also observed a statistically significant (p<0.05) elevation in LPO levels of vitiligo patients with NB-UVB phototherapy alone as well as in patients receiving anti-oxidant and NB-UVB phototherapy. Our results show that on the one hand antioxidant supplementation decreases oxidative stress in vitiligo patients while on the other hand, NB-UVB phototherapy exerts the overproduction of lipid peroxides.
Authors and Affiliations
B. Rathore et al.
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