Effect of Antibiotic Prophylaxis on Serum CRP Level Immediately Following Periodontal Treatment: An Experimental Clinical Study
Journal Title: International Journal of Oral and Dental Health - Year 2017, Vol 3, Issue 2
Abstract
Background The immediate rise in serum C-reactive Protein (CRP) levels associated with the delivery of the subgingival instrumentation and the associated bacteremia and tissue damage was shown shortly after periodontal treatment was delivered. However, additive effect of the protection against bacteremia on immediate alterations in CRP levels has not been evaluated. Aim of this study was to determine the immediate effect of single session of non-surgical periodontal treatment with or without antibiotic prophylaxis on serum levels of CRP. Methods Forty systemically healthy subjects with chronic periodontitis were randomly assigned two groups. Clinical periodontal parameters and smoking status were recorded. Serum CRP levels were determined using nephelometric method at baseline and 1, 3 and 7 days after treatment. Results Except for the difference between baseline and day 7, there were significant differences (p < 0.001) in CRP levels between the evaluation days in both groups. However, the differences between the groups for the alterations were not significant. Conclusions In agreement with previous observations, periodontitis and traumatic effect of periodontal treatment seem to contribute to systemic inflammation detected by the presence of immediate rise in CRP level. Additional administration of prophylactic antibiotic did not alter this immediate systemic response.
Medication-Related Osteonecrosis of the Jaw with the mTOR Inhibitor Everolimus in a Patient with Estrogen-Receptor Positive Breast Cancer: A Case Report
Background: In the treatment of bone metastases from breast cancer, bisphosphonates are considered the cornerstone of treatment to prevent adverse skeletal related events. Intravenous bisphosphonates reduce bone resorpti...
Late Diagnosis of CGCL in a Noonan Syndrome Patient
Noonan syndrome is an autosomal dominant condition with variable phenotypic expressions including short stature, distinct craniofacial features, congenital heart anomalies, and developmental delay. The main craniofacial...
Partial-mouth Periodontal Examination Protocols for Population-based Surveillance of Periodontitis
Objective: This study aimed at evaluating bias in the estimates of prevalence of moderate and severe periodontitis for each of four previously identified partial-mouth periodontal examination protocols (PMPE) compared to...
Prevalence and Genotypes of Candida albicans from Necrotising Periodontal Disease and the Tongue
Objectives: The objectives were to determine the prevalence of Candida albicans in lesions of necrotising periodontal disease (NPD) and on the tongue of patients and to compare the fingerprinting patterns of C. albicans...
Upper Airways Modification Following Mandibular Thrust Treatment
Aim The aim of the study is to evaluate morphological changes in upper airways in patients undergoing therapy with removable functional orthopedic devices used in the treatment of the II skeletal classes by mandibular re...