EFFECT OF ANTIOXIDANTS AND ANTIBIOTICS ON LEVELS OF SEMINAL OXIDATIVE STRESS IN LEUKOCYTOSPERMIC INFERTILE MEN
Journal Title: Indian Journal of Clinical Biochemistry - Year 2006, Vol 21, Issue 1
Abstract
Defective sperm function is the most common cause of infertility. A prospective study was carried out to correlate the concentration of nitrite (the stable metabolite of nitric oxide) in seminal plasma with leukocytospermia, and sperm membrane integrity. Total Fifty-seven normozoospermic subjects with and without leukocytospermia visiting the Infertility clinic at KH and MRC, Karad, were included in the present study. Semen samples were checked for sperm concentration, total sperm count, sperm motility, seminal leukocyte concentration and sperm membrane integrity as Hypoosmotic Swelling Test. Similarly the concentration of nitrite in seminal plasma was measured by Griess reaction and total antioxidant power measured as ferric reducing ability of plasma. The concentration of nitrite in seminal plasma was found to be raised with significantly increased leukocyte concentration in semen. Also significantly lowered levels of total antioxidant power along with defective sperm function was observed. Our results suggest that supplementary treatment of antioxidants with antibiotic for leukocytospermic infertile male patients may improve the sperm membrane integrity.
Authors and Affiliations
Sunil B. Yadav1, Adinath N. Suryakar2, Anil D. Huddedar3 and Pramod S. Shukla1
Keywords
Related Articles
- EP ID EP107458
- DOI -
- Views 126
- Downloads 0
COMPARATIVE STUDY ON LIPID PEROXIDATION AND ANTIOXIDANT VITAMINS E AND C IN FALCIPARUM AND VIVAX MALARIA
Reactive oxygen species are thought to be involved in the pathogenesis of Malaria. To assess the extent of oxidative stress, a study was conducted in patients with Plasmodium falciparum malaria and Plasmodium Vivax mal...
STUDIES ON THE AGE DEPENDENT CHANGES IN SERUM ADENOSINE DEAMINASE ACTIVITY AND ITS CHANGES IN HEPATITIS
Serum Adenosine deaminase (ADA) activity in normal healthy control subjects increases upto 30 years, remains steady between 31-60 years of age and shows a steep increase in the age group of 61-70 years. This was compar...
ROLE OF ETHANOL ON ALUMINUM INDUCED BIOCHEMICAL CHANGES ON RAT BRAIN
Aluminum and alcohol, both are well-accepted neurotoxin. The plausible mechanisms for their neurotoxicity are also common. Therefore, the effect of ethanol on aluminum induced biochemical changes in rat brain is being...
EFFECT OF INCREASING DURATION OF DIABETES MELLITUS TYPE 2 ON GLYCATED HEMOGLOBIN AND INSULIN SENSITIVITY
Non-insulin dependent diabetes mellitus (NIDDM) is the most rapidly growing chronic metabolic disorder in the world. With advancement in the age and duration of diabetes there is a gradual tendency for the level of blo...
INTERNET RESOURCES AND BIOCHEMISTRY
The Internet is a massive expanding body of information, which is likely to play a significant role for clinical Biochemists and researchers in patient health care across the world. This expansion has been matched by a...