EFFECT OF ANTIOXIDANTS AND ANTIBIOTICS ON LEVELS OF SEMINAL OXIDATIVE STRESS IN LEUKOCYTOSPERMIC INFERTILE MEN
Journal Title: Indian Journal of Clinical Biochemistry - Year 2006, Vol 21, Issue 1
Abstract
Defective sperm function is the most common cause of infertility. A prospective study was carried out to correlate the concentration of nitrite (the stable metabolite of nitric oxide) in seminal plasma with leukocytospermia, and sperm membrane integrity. Total Fifty-seven normozoospermic subjects with and without leukocytospermia visiting the Infertility clinic at KH and MRC, Karad, were included in the present study. Semen samples were checked for sperm concentration, total sperm count, sperm motility, seminal leukocyte concentration and sperm membrane integrity as Hypoosmotic Swelling Test. Similarly the concentration of nitrite in seminal plasma was measured by Griess reaction and total antioxidant power measured as ferric reducing ability of plasma. The concentration of nitrite in seminal plasma was found to be raised with significantly increased leukocyte concentration in semen. Also significantly lowered levels of total antioxidant power along with defective sperm function was observed. Our results suggest that supplementary treatment of antioxidants with antibiotic for leukocytospermic infertile male patients may improve the sperm membrane integrity.
Authors and Affiliations
Sunil B. Yadav1, Adinath N. Suryakar2, Anil D. Huddedar3 and Pramod S. Shukla1
Keywords
Related Articles
- EP ID EP107458
- DOI -
- Views 114
- Downloads 0
Association of Plasma Level of Thiobarbituric Acid Reactive Substances with Extent of Hepatocellular Injury in Preterm Infants with Cholestatic Jaundice
The present study was designed to determine the association between extent of hepatocellular injury and plasma level of thiobarbituric acid reactive substances (TBARS) in pre term infants with cholestasis. Preterm infant...
IMPAIRED HYPOTHALAMIC-PITUITARY-GONADAL AXIS FUNCTION IN MEN WITH DIABETES MELLITUS
In view of association of diabetes mellitus and male infertility, present study was designed to investigate the functional status of hypothalamic pituitary gonadal (HPG) axis in diabetic men. Thirty-five diabetic men (BM...
SIGNIFICANCE OF TUMOR MARKERS IN LUNG CANCER
The objective was to test the utility of the cytokeratins CYFRA 21-1, tissue polypeptide specific antigen (TPS), Neuron specific enolase (NSE) and Carcino Embryonic antigen (CEA) in patients with lung cancer and in the...
COMPARATIVE ANALYSIS OF RBC MEMBRANE FATTY ACIDS, PROTEINS AND GLYCOPHORIN IN PATIENTS WITH HETEROZYGOUS BETA THALASSEMIA AND IRON DEFICIENCY ANEMIA
Membrane lipid and protein composition was compared in erythrocytes from iron deficiency anemia (IDA) and heterozygous beta thalassemia patients. The study was planned to correlate the influence of iron deficiency with...
LIPID PROFILE IN LEUKEMIA AND HODGKIN’S DISEASE
A number of epidemiologic studies has been published in recent years showing an increase risk of death from cancer in subjects with low plasma cholesterol levels. Although several authors proposed that hypocholesterole...