Effect of Aqueous Extract of African Star Apple (Chrysophyllum Albidum) on the Glucose and Triacylglycerol Concentrations in Albino Rats
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 8
Abstract
This study investigated the effects of aqueous bark extract of unripe Chrysophyllum albidum on plasma glucose and triacylglycerol concentrations in albino rats. Six normal male albino rats of average weight 160g obtained at eight weeks were randomly categorized into two groups of three rats each after one week of acclimatization. Aqueous bark extract of unripe Chrysophyllum albidum was administered to the test rats for 28 days. Blood samples collected periodically from the tail of the rats were analyzed for glucose and triacylglycerol levels by spectrophotometric method. Statistical analysis of results showed that the extract caused significant decreases in glucose and triacylglycerol concentrations on days 6, 12, 18, 24 and 28 when compared with the normal control (P<0.05). Histological report showed that the aqueous bark extract of unripe Chrysophyllum albidum was neither hepatotoxic nor nephrotoxic and was well tolerated by the heart. Therefore, this extract may also be useful in the treatment of diabetes mellitus.
Authors and Affiliations
Prof. T. P. Prohp.
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