Effect of Aqueous Extract of Persea americana Seed on Blood Glucose in Alloxan-induced Diabetic Wistar Rats
Journal Title: Asian Journal of Medicine and Health - Year 2017, Vol 9, Issue 1
Abstract
Alternatively known as grape sugar, Glucose, a monosaccharide (C6H12O6) is often found in honey and the juices of many fruits. It is the sugar most often produced by hydrolysis of complex compounds from plants (natural glycosides) and forms a major constituent of the blood of animals. One of the major implications of increased blood glucose is Diabetes Mellitus. In spite of its life-threatening complications, the issue of cost, and appropriate dosage administration (with synthetic drugs) remain an issue. This study was undertaken to determine the hypoglycemic (glucose lowering) activity of Persea americana seed extract in the blood of alloxan-induced, diabetic (hyperglycemic) wistar rats. To achieve this, Thirty-Five (35) Wistar rats (140 – 200 g) were assigned into seven groups of 5 rats each with group A serving as normal control. While Groups B through E were respectively treated with 250 mg/kg and 500mg/kg of Persea seed extract (Non-diabetic rats), Alloxan (diabetic control), and Alloxan (diabetic, then treated with 50 mg/kg of metformin), Groups F and G were diabetic rats which respectively received 250 mg/kg and 500mg/kg of Persea seed extract. After 28 days of administration, rats were sacrificed with blood samples collected for analysis of glucose levels. Pancreatic tissues were also harvested for histopathological extermination. Results show an increase in body weight (20.39 – 26.32%) of diabetic treated rats (group E) as compared to diabetic control (Group D). Though blood glucose levels for group E reduced significantly (at p<0.05) in a dose-dependent manner as compared to elevated levels in diabetic control, no significant changes were observed in normal treated rats (group D) as against normal control (Group A). Histopathology of the pancreas revealed a degeneration in the islet cells of diabetic untreated groups F and G compared to non-diabetic group A.
Authors and Affiliations
A. A. Aigbiremolen, R. N. Ativie, M. E. Aisuodionoe, O. M. Odigie, J. C. Igweh
Keywords
Related Articles
- EP ID EP336883
- DOI 10.9734/AJMAH/2017/37955
- Views 55
- Downloads 0
Prevalence of Schistosomia haematobium and Staphylococcus aureus among Pregnant Women in Akure
Schistosomiasis is one of the most important parasitic disease of man. Staphylococcus aureus has also been observed as one of the causal agents of Urinary Tracts Infectionsand can be regarded as threat. This study focuse...
Impact of Chronic Periodontitis on Systemic Conditions: A Review
The oral cavity might well be thought of as the window of the human body due to the extent of the inflammatory burden caused by periodontal disease. This can influence systemic diseases with a similar inflammatory pathol...
Computed Tomography Imaging Features of Chronic Headaches in Abuja, Nigeria
Headache is one of the commonest presenting complaints among patients in the emergency room and in general outpatient clinics. Computed Tomography, CT is a veritable diagnosing tool in the evaluation of both intracranial...
Plasmid Profile of Multidrug Resistant Bacteria Isolated from Wound Swabs from Hospital Patients in Akure, Nigeria
A total of 347 clinical wound swabs were obtained in Ondo State Specialist Hospital. Isolated pure cultures of bacteria were subjected to various morphology and biochemical tests. The isolates were identified using Berge...
Prevalence and Risk Factors of Dental Caries among Preparatory School Children, Menoufia Governorate, Egypt
Objectives: Estimating the prevalence of dental caries among preparatory school children as well as identifying the possible risk factors and determining the correlation between dental caries and total antioxidant capaci...