Effect of Aqueous Extract of Persea americana Seed on Blood Glucose in Alloxan-induced Diabetic Wistar Rats
Journal Title: Asian Journal of Medicine and Health - Year 2017, Vol 9, Issue 1
Abstract
Alternatively known as grape sugar, Glucose, a monosaccharide (C6H12O6) is often found in honey and the juices of many fruits. It is the sugar most often produced by hydrolysis of complex compounds from plants (natural glycosides) and forms a major constituent of the blood of animals. One of the major implications of increased blood glucose is Diabetes Mellitus. In spite of its life-threatening complications, the issue of cost, and appropriate dosage administration (with synthetic drugs) remain an issue. This study was undertaken to determine the hypoglycemic (glucose lowering) activity of Persea americana seed extract in the blood of alloxan-induced, diabetic (hyperglycemic) wistar rats. To achieve this, Thirty-Five (35) Wistar rats (140 – 200 g) were assigned into seven groups of 5 rats each with group A serving as normal control. While Groups B through E were respectively treated with 250 mg/kg and 500mg/kg of Persea seed extract (Non-diabetic rats), Alloxan (diabetic control), and Alloxan (diabetic, then treated with 50 mg/kg of metformin), Groups F and G were diabetic rats which respectively received 250 mg/kg and 500mg/kg of Persea seed extract. After 28 days of administration, rats were sacrificed with blood samples collected for analysis of glucose levels. Pancreatic tissues were also harvested for histopathological extermination. Results show an increase in body weight (20.39 – 26.32%) of diabetic treated rats (group E) as compared to diabetic control (Group D). Though blood glucose levels for group E reduced significantly (at p<0.05) in a dose-dependent manner as compared to elevated levels in diabetic control, no significant changes were observed in normal treated rats (group D) as against normal control (Group A). Histopathology of the pancreas revealed a degeneration in the islet cells of diabetic untreated groups F and G compared to non-diabetic group A.
Authors and Affiliations
A. A. Aigbiremolen, R. N. Ativie, M. E. Aisuodionoe, O. M. Odigie, J. C. Igweh
Keywords
Related Articles
- EP ID EP336883
- DOI 10.9734/AJMAH/2017/37955
- Views 71
- Downloads 0
No Association between Helicobacter Pylori Infection and Type 2 Diabetes Mellitus; A Case-control Study in the North-Western Part of Ghana
Background: Patients with diabetes mellitus are prone to infections as a result of impaired immune status as a consequence of hyperglycemia. Previous studies addressing the relationship between Helicobacter pylori (H. py...
Demographic, Clinical and Therapeutic Characteristics of Children Aged 0-15 years with Nephrotic Syndrome: A Retrospective Study of the Komfo Anokye Teaching Hospital, Kumasi, Ghana
Background: Nephrotic syndrome is a common childhood renal disease globally with a penchant for the early years of life and has generated a lot of interest among paediatricians and nephrologists. Aim: This study aimed to...
Rescue and Emergency Management of a Water-Related Disaster: A Bangladeshi Experience
Background: The Padma, one of the largest rivers in the world, is crossed by thousands of people every day by boat or launch (a local made ferry). However, the number of launches is insufficient, and launches are frequen...
Some Haematological and Haemostatic Indexes in Young Semi-vegetarians in Sub-Sahara Africa
Background: The protective power of vegetarian diet against diseases is not a hype but there is a scarcity of information concerning the impact of semi-vegetarian meals on wellbeing, especially, in young adults living in...
Metabolic Syndrome and Kidney Damage: Prevalence and Assessment of Risk among Apparently Healthy Resident of Ado Ekiti, South West Nigeria
Background: Individuals with metabolic syndrome are at increased risk of developing chronic kidney disease. Objective: There is limited information on the relationship between metabolic syndrome and CKD among Nigerian p...