Effect of aqueous extract of Terminalia superba Engl. et Diels (Combretaceae) stem bark on the biochemical parameters of Ratus norvegicusc
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 12
Abstract
Terminalia superba Engl. and Diels (Combretaceae) is a medicinal plant used for the treatment of gastric ulcer in Côte d'Ivoire. In order to verify the safety of this plant, each day, during 28 days, aqueous extract of the stem bark is administered orally to three groups of rats at doses 125, 250 and 500 mg / kg body weight. The control group received distilled water. Every week, rats blood samples collected into plain tubes were used to determine the biochemical parameters such as transaminases AST and ALT, urea, creatinine, triglycerides, glycaemia and total cholesterol by enzymatic and kinetic methods. Results showed that at the fourth week, the doses 250 and 500 mg / kg body weight induced a significant decrease in urea and triglycerides and a significant increase in total cholesterol. Concerning ALT, AST, creatinine and glycaemia, no significant variation was observed. The use of aqueous extract of Terminalia superba stem bark would not be toxic to the liver and kidneys at the doses 125 to 500 mg / kg body weight.
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