Effect of Beta-Blockers on Number of Osteoblasts and Osteoclasts in Alveolar Socket Following Tooth Extraction in Wistar Rats
Journal Title: Journal of Dentistry, Shiraz University of Medical Sciences - Year 2017, Vol 18, Issue 1
Abstract
Statement of the Problem: Various researchers have suggested the use of β2-adrenergic receptor antagonists in prevention or treatment of bone resorption. Purpose: This study aimed to evaluate the effect of β2-adrenergic receptor antagonists on number of osteoclasts and osteoblasts involved in the healing of extraction socket of maxillary first molar in rats. Materials and Method: Maxillary first molars of 40 rats were extracted and divided into two groups. The test group received 0.1 mg/kg propranolol intraperitoneally daily. The controls received normal saline. At days 7, 14, 21 and 28 post-extraction, 5 rats were euthanized from each group. Maxillary bone was resected and the mean number of osteoblasts and osteoclasts in tooth socket was measured. Results: After 1 week, the number of osteoclasts in the controls was significantly higher than the test group. A significant increase in the number of osteoclasts in both groups at week 1 was observed compared to the following weeks (p< 0.05). The number of osteoblasts in the controls at second week reached its maximum rate but stayed constant in the 3rd and 4th weeks. Osteoblasts in the test group increased similar to the controls but reached its maximum at 3rd week and showed a significant increase compared to the controls (p< 0.05). Conclusion: β2 adrenergic receptor antagonists decrease the number of osteoclasts and increase the number of osteoblasts during extraction socket healing.
Authors and Affiliations
Katayoun Sadr, Amirala Aghbali, Makan Sadr, Hamed Abachizadeh, Maryam Azizi, Mehran Mesgari Abbasi
Keywords
Related Articles
- EP ID EP238829
- DOI -
- Views 114
- Downloads 0
Does the Angulation of an Impacted Mandibular third Molar Affect the Prevalence of Preoperative Pathoses?
Statement of the Problem: The removal of a third molar tooth associated with a pathological condition is usually an easy decision. However, it is necessary for clinicians to know about the prevalence of preoperative path...
Shear Bond Strength of a Multi-Mode Adhesive to Bur-Cut and Er,Cr:YSGG Lased Dentin in Different Output Powers
Statement of the Problem: Universal or multi-mode adhesives are new adhesive systems that can be used in both etch-and-rinse (ER) and self-etch (SE) modes. Lesser technical sensitivity and dual use of these adhesives hav...
Oro-Antral Fistula Repair With Different Surgical Methods: a Retrospective Analysis of 147 Cases
Statement of the Problem: An oro-antral fistula (OAF) creates a passage for oral microbes into maxillary sinus with numerous possible complications. Purpose: This retrospective study evaluates the success of three diffe...
Congenital Gingival Granular Cell Tumor: A Case Report
The congenital gingival granular cell tumor (CGCT), also as known as congenital epulis, is an unusual benign oral mucosal lesion in newborns. A two-day-old female patient was admitted to the Department of Pediatric Denti...
Effect of 940nm Diode Laser Irradiation on Microtensile Bond Strength of an Etch and Rinse Adhesive (Single Bond 2) to Dentin
Statement of the Problem: Laser can influence bonding mechanism by increasing the penetration depth of adhesive in smear layer. The effect of 940 nm diode laser on microtensile bond strength of adhesive to dentin has not...