Effect of Buspirone on Fetuses of the Pregnant Rats
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 2
Abstract
<span>Aim of the work</span><span>: the purpose of this study was to detect effect of buspirone hydrochloride (Buspar) on the structure of cerebellum cortex of the fetuses of the pregnant rats. </span><span>Material and methods: </span><span>buspirone hydrochloride tablets are an antianxiety. Buspirone hydrochloride (buspar) tablets were obtained from SmithKline Beecham-Haram-Giza- Egypt. Thirty pregnant female rats were randomly categorized into three groups (Ten pregnant female rats in each group). Group </span><span>I </span><span>(control group) </span><span>pregnant rats were administered oral doses of distilled water, </span><span>group </span><span>II</span><span>: </span><span>in this group pregnant rats were treated with buspirone hydrochloride, they were administered oral doses of drug in the distilled water equivalent to 0.27 mg/100g. body weight/day respectively for 15 days from the 6</span><span>th </span><span>day to the 20</span><span>th </span><span>day of gestation. </span><span>, group </span><span>III</span><span>: </span><span>pregnant rats were treated with to oral doses of buspirone hydrochloride in the distilled water equivalent to 0.41 mg/100g. body weight/day respectively for 15 days from the 6</span><span>th </span><span>day to the 20</span><span>th </span><span>day of gestation. Pregnat rats of all groups were sacrificed on the 20</span><span>th </span><span>day of gestation and their fetuses were obtained for the histopathological and histochemical studies. </span><span>Results: </span><span>treatment of pregnant rats with buspirone hydrochloride (buspar) showed many dystrophic changes in brain of their fetuses; these changes were more obvious in case of the </span><span>toxic </span><span>dose of buspirone which resulted in some sorts of neurotoxic structural changes in the cerebellum of fetuses of pregnant rats as evident by deformity in the cerebellar layers and degeneration of Purkinje cells. </span><span>Conclusions: </span><span>buspirone hydrochloride (buspar) has many adverse effects on the fetal cerebellum tissue.<br /> </span>
Authors and Affiliations
Eman Helal
Keywords
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- EP ID EP584056
- DOI 10.21608/ejhm.2018.9065
- Views 188
- Downloads 0
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