Effect of Caffeine (Nescafé) on Serum Testosterone Levels in Male Wistar Rats
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 10
Abstract
Caffeine is one of the most frequently ingested pharmacological agents. It is contained in several beverages; with dearth of literature on its effect on reproductive parameters. This present study aimed to determine the effect of aqueous solution of caffeine on serum testosterone level in wistar rats. Forty-five male albino wistar rats weighing between 120g-200g were obtained for this study and were grouped based on their body weight into five groups of nine rats each. Group 1, served as the control and received water rats chow ad libitum while groups 2,3,4 and 5, serve as test groups and received 20mg/kg, 60mg/kg, 100mg/kg and 140mg/kg body weight doses of caffeine respectively, orally once daily for 21days. Three animals were sacrificed from each group on the 7th, 14th and 21st day following administration. Blood samples were collected through cardiac puncture for serum testosterone analysis and the testes were harvested on the 21st day for histopathological examination. There was a dose-dependent significant (p<0.05) increase in serum testosterone level on the 7th, 14th and 21st day for 100mg/kg and 140mg/kg; and a significant (p<0.05) increase in 21st day for 60mg/kg between dose of caffeine when compared to the control. The histopathological examination of the testes showed normal testicular architecture; indicative of normal testicular integrity. These findings revealed that caffeine [22] may have a possible potential to stimulate spermatogenesis. Hence its consumption may lead to an increase in sex drive and improve male factor fertility.
Authors and Affiliations
Onuoha SC, Edo EG
Keywords
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