Effect of calcium dobesilate on fundus microcirculation in patients with diabetic retinopathy and cataract
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 5
Abstract
AIM: To analyze the effect of calcium dobesilate combined with hypoglycemics for patients with diabetic retinopathy(DR)and cataract, and the influence on microcirculation of eye fundus, hypoxia inducible factor-1α(HIF-1α), vascular endothelial growth factor(VEGF)level. <p>METHODS: Totally 98 DR patients with cataract(126 eyes)from January 2013 to December 2015 in our hospital were selected as the research objects, and were divided into two groups randomly(treatment group: 64 eyes in 49 patients, control group: 62 eyes in 49 patients). The control group was treated with acarbose tablet and metformin, while treatment group was treated with calcium dobesilate additionally. The clinical effect, the glycemic control effect, serum HIF-1α and VEGF level, eye function and fundus microcirculation of two groups after 12mo were compared. <p>RESULTS: After 12mo, the total effective rates of two groups were 87.5%, 61.3% respectively, which indicated significantly difference(<i>P</i><0.05); the vision of treatment group was significantly higher than that of control group(<i>P</i><0.05). Two groups' blood glucose level decreased significantly, and no significant difference between two groups(<i>P</i>>0.05). After 1-month treatment, the plasma viscosity, erythrocyte aggregation index, erythrocyte deformability index, erythrocyte sedimentation rate and hematocrit in the treatment group were significantly lower than those in the control group(<i>P</i><0.05). The PSV and EDV of the posterior ciliary artery and central artery in the treatment group were significantly higher than those in the control group(<i>P</i><0.05), and RI was significantly lower than that in the control group(<i>P</i><0.05). After 12-month treatment, the HIF-1α level of two groups were 35.90±11.36mmol/L, 46.75±12.08mmol/L respectively; the VEGF of two groups level were 89.72±13.61mmol/L, 110.30±16.74mmol/L, respectively, the treatment group's HIF-1α level and VEGF were significantly lower than control group(<i>P</i><0.05), and both decreased significantly after treatment(<i>P</i><0.05). <p>CONCLUSION: Calcium dobesilate combined with hypoglycemics can effectively increase the clinical effect in the treatment of retinopathy diabetic cataract, effectively control blood glucose, improve microcirculation of eye fundus, decrease HIF-1α, VEGF level, inhibit angiogenesis.
Authors and Affiliations
Xue-Mei Wu
Keywords
Related Articles
- EP ID EP581422
- DOI 10.3980/j.issn.1672-5123.2018.5.26
- Views 114
- Downloads 0
Postpartum regular massage on lacrimal sac to prevent neonatal dacryocystitis
AIM: To early massage lacrimal sac to prevent and reduce the neonatal dacryocystitis. <p>METHODS: We collected 4 048 cases of neonatal, there were 2 650 cases of natural birth including 5 300 eyes and 1 398 cases of Cesa...
Mechanism and effect of H<sub>2</sub>S on oxidative stress in diabetic cataract rats
AIM: To explore the effect of hydrogen sulfide(H<sub>2</sub>S)on oxidative stress in diabetic cataract rats and its mechanism. <p>METHODS:SD rats were randomly divided into control group, diabetic group, low-dosage NaHS-...
Curative effect of different surgical approaches for orbital tumors
AIM: To analyze the clinical effect of different surgical approaches for orbital tumors. <p>METHODS: A total of 52 patients(56 eyes)with orbital tumors who were admitted to the hospital from January 2012 to June 2017 wer...
Soft corneal contact lens for postoperative comfort in patients with recurrent pterygium function
AIM:To evaluate the effect of soft contact lens on the comfort of postoperative patients with recurrent pterygium. <p>METHODS: For 100 eyes of 98 patients after recurrent pterygium excision, the conjunctival implant with...
Effect of miR-138 on the antioxidant function of lens epithelial cells affected by age-related cataracts
AIM: To investigate the effects and mechanism of miR-138 in mediating the antioxidant function of lens epithelial cells affected by age-related cataracts. <p>METHODS: Real-time quantitative PCR(RT-qPCR)was used to detect...