Effect of calcium & Vit D supplementation on incidence/severity of ovarian cancer
Journal Title: International Journal of Medical and Health Research - Year 2019, Vol 5, Issue 1
Abstract
Several epidemiological studies have evaluated the association between calcium intake and the reduced risk of ovarian cancer. However, the results of these studies remain controversial. Among 15 epidemiological studies involving 493,415 participants and 7453 cases eligible for this meta-analysis, 13 studies were about dietary calcium intake, 4 studies about dairy calcium intake and 7 studies about dietary plus supplemental calcium intake. When comparing the highest with the lowest intake, the pooled RRs of ovarian cancer were 0.80 (95% CI 0.72–0.89) for dietary calcium, 0.80 (95% CI 0.66–0.98) for dairy calcium and 0.90 (95% CI 0.65–1.24) for dietary plus supplemental calcium, respectively. Dietary calcium was significantly associated with a reduced risk of ovarian cancer among cohort studies (RR = 0.86, 95% CI 0.74–0.99) and among case-control studies (RR = 0.75, 95% CI 0.64–0.89). Based on these previous studies we designed a study to assess the effect of Ca supplementation / dietary intake with the occurrence / severity of ovarian cancer. In subgroup analysis by ovarian cancer subtypes, we found a statistically significant association between the dietary calcium (RR = 0.69, 92% CI 0.66–0.81) and the risk of epithelial ovarian cancer. This meta-analysis indicated that increased calcium intake might be inversely associated with the risk of ovarian cancer; this still needs to be confirmed by larger prospective cohort studies.
Authors and Affiliations
Dr. Seema Mishra, Dr. Kamlesh
Keywords
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