Effect of Carica papaya (L) Leaves on Haematological Parameters in Ccl4-induced Wistar Albino Rats
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 16, Issue 3
Abstract
Aims: To investigate the effect of Carica papaya leaves on some haematological parameters (PCV, RBC, Hb, WBC and differential blood counts) were investigated. Place and Duration of Study: Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Amassoma, Bayelsa-State, Nigeria, between. Methods: Thirty male albino rats were randomly allotted to five groups of six rats per group. Haemoglobin (Hb) was determined spectrophotometrically by the cyanomethaemoglobin method, Red blood cells (RBC), was estimated by haemocytometer, using adopted standard procedure. Group1 (negative control) were fed with 100% rat feed. Groups 2- 4 were pretreated with 10, 30 and 50% C. papaya L respectively, while Group 5 (normal control) received 100% rat feed. Rats in groups (1-4), were injected with CCl4 (0.5 ml/kg body weight in 0.5 ml olive oil) on the 29th day while rats in group 5 were not administered with CCl4 (normal control). Results: The results were statistically analyzed using one-way analysis of variance (ANOVA). There were significant increases (p≤ 0.05) in the levels of Hb, PCV, RBC, lymphocytes and decreased WBC and neutrophils in rats in group 5 (normal control) as against the negative control (group 1). Rats groups pretreated with 10, 30 and 50% Carica papaya (groups 2, 3 and 4 respectively), showed significant increased (p≤ 0.05) PCV, RBC and Hb levels, when compared with untreated rats (group 1). Rats that were administered with CCl4 only (negative control), showed significant increases (p≤ 0.05) in the levels of WBC and neutrophils. However, incorporation of 10, 30 and 50% Carica papaya in groups 2, 3 and 4 respectively, significantly decreased the levels of WBC and neutrophils, when compared with rats in untreated group 1. Monocytes levels significantly increased (p≤ 0.05) in rats pre-treated with 30% and 50% Carica papaya (groups 3 and 4 respectively). While, there was zero level of basophils in all the groups. Conclusion: Carica papaya L, may therefore possess and confer erythropoietic properties on rats pretreated groups as evident in the increased levels of Hb, PCV, RBC and lymphocytes.
Authors and Affiliations
O. J. Sule, A. R. Abdu, K. Kiridi
Keywords
Related Articles
- EP ID EP341291
- DOI 10.9734/BJMMR/2016/13686
- Views 67
- Downloads 0
The Evaluation of Laparoscopic Orchiopexy on the Treatment of Non-palpable Undescended Testes
Objectives: Cryptorchidism is the most frequent birth anomaly in boys with 2-5% prevalence in full term infants. This anomaly is associated with an increased risk of testicular cancer and infertility as well as hernia, t...
Information Asymmetry in Financial Forecasting within Healthcare and Simple Methods to Overcome this Deficiency
Aims: To explore the interplay between information asymmetry and financial forecasting in the context of the English National Health Service (NHS). Study Design: Synthesis of the political context of the English NHS and...
Review of Contraception with Depot Medroxyprogesterone Acetate at the University of Port Harcourt Teaching Hospital, Port Harcourt, Southern Nigeria
Aims: To re- evaluate the use, effectiveness, acceptability and side effects of depot medroxyprogesterone acetate in Port Harcourt, Southern Nigeria. Study Design: Descriptive retrospective analysis. Place and Duration...
Identical Twins Rhinoplasty; Twice the Challenge
In identical twins, they have strong special environmental, psychological and social relationships. Rhinoplasty is one of the most popular procedure and in this group of the population carries distinct consideration rega...
An Unusual Presentation of a Primaryeosinophilic Gastrointestinal Disorder (Case Report)
Primary Eosinophilic gastroenteritis is an uncommon inflammatory gastrointestinal disease affecting children first described in 1937.Its incidence is 1/100000. The eosinophilic infiltration can occur in one or more segme...