Effect of Centella asiatica against anti-tuberculosis drugs-induced hepatotoxicity: Involvement of mitochondria and oxidative stress
Journal Title: The Journal of Phytopharmacology - Year 2014, Vol 3, Issue 4
Abstract
The liver is an integral organ in the body and plays a vital role for the metabolism of endogenous and exogenous agents. Drug-induced liver toxicity is one of most common cause of liver injury. It accounts for approximately one-half of the cases of acute liver failure and mimics all forms of acute and chronic liver disease. Hepatotoxicity is associated with the first line antituberculosis drugs such as isoniazid and rifampicin. Therefore, there is need of pharmacological interventions for the treatment of hepatotoxicity. The present study was designed to evaluate the hepatoprotective effect of the Centella asiatica extract on anti-TB drugs-induced hepatotoxicity. Hepatotoxicity was induced by administration of anti-TB drugs (isoniazid and rifampicin). Hepatotoxicity was assessed by significant elevation in oxidative stress, mitochondrial complex alterations and elevated levels of liver marker enzymes. Treatment with Centella asiatica (20, 40 mg/kg p.o.) attenuated the anti-TB drugs induced oxidative stress, mitochondrial complex alterations and elevated levels of liver marker enzymes (viz. SGOT, SGPT, ALP). Histopathological studies also show the promising effect. Therefore, the present study shows the hepatotoprotective effect of Centella asiatica. Therefore, Centella asiatica could be a new pharmacological intervention in the treatment of hepatotoxicity.
Authors and Affiliations
Vinay Kumar, Ankur Sharma , Lalit Machawal, K. Nagarajan, Shadab A. Siddiqui
Keywords
Related Articles
- EP ID EP49578
- DOI -
- Views 204
- Downloads 0
Phytochemical screening and cytotoxicity of selected plants used as anthelmintics in Loitoktok Sub-County, Kenya
The practice of traditional medicine is as old as the human race, and plants are an important source of research and development of new drugs. Anthelmintic resistance in human and animal pathogenic helminthes has been...
Antimicrobial screening of free and bound flavonoid from the bark of Terminalia arjuna
Continuous use of antibiotics results in the increased number of antibiotic resistant strains of microorganisms. Thus, a diverse arsenal of new antimicrobial agents is urgently needed to combat the diminishing efficacy...
Preliminary Phytochemical Analysis of Leaf and Bark methanolic extract of Sesbania grandiflora
Sesbania grandiflora L. (family- Leguminosae) is a small erect, fast-growing, and sparsely branched tree that reaches 10 m in height. The bark of this species is light gray, corky and deeply furrowed and the wood is so...
Cytotoxic effect of Berberis libanotica roots extracts on human cancer cells and antioxidant activities
In the present study, we evaluated the cytotoxic effect and the antioxidant activity of methanolic and ethanolic roots extracts obtained from Berberis libanotica a Lebanese medicinal tree. Cytotoxic activity was assesse...
Ethnomedicinal, Pharmacological and Antimicrobial Aspects of Moringa oleifera Lam.: A review
The inclusive information is provided in present review on traditional uses, antimicrobial activity and pharmacology of Moringa oleifera Lam. It is commonly known as ‘drumstick tree’. M. oleifera is alternative tonic,...