EFFECT OF CENTRALLY ADMINISTERED NITRIC OXIDE MODULATORS IN CARRAGEENIN-INDUCED NOCICEPTION IN RATS
Journal Title: International Journal of Agricultural Science and Research (IJASR) - Year 2017, Vol 7, Issue 1
Abstract
Possible modulation of carrageenin induced nociception by centrally (ICV) administered nitric oxide (NO) modulators was investigated. In rat, inhibitors of nitric oxide synthase inhibitors (NOS), precursor of nitric oxide (NO) with SIN-1, L-Name and haemoglobin (Hb) was explored. Nitric acid donors and scavengers are also evaluated. The pain threshold capacity is increased significantly while administration of NOS inhibitors and NO scavenger Hb whereas as hyperalgesic effect was resulted while administration of nitric oxide donors SIN-I, SNP and L-arginine. The nociceptive behavior of rat was failed to alter by D-arginine while co-administration of SIN-I with L-Name and haemoglobin found to increase the threshold level. These results showed alteration of nociceptive transmission induced by Carrageenin in rats after administration of nitric oxide modulators.
Authors and Affiliations
JADAV SARMA, SURENDRA KUMAR TANDON, SANJIB KHARGHARIA, HIMANGSHU BARUAH
Keywords
Related Articles
- EP ID EP222791
- DOI -
- Views 127
- Downloads 0
Sensor Fusion for Normally Distributed Noise Estimation by Snapshots Techniques Using Foot and Mouth Diseases Massive Data Sets in Karnataka State
The foot and mouth disease (FMD) is one of the highly contagious viral diseases causing illness in cloven- footed animals. The outbreak of this disease can grave deleterious economic burden on national GDP and global eco...
A Study on Annual Family Consumption Expenditure of Small and Marginal Farmers in Rural Areas of Madurai District
Man is always with a bundle of desires. Every Human in the world has got a unique needs, wants and desires. To satisfy the basic needs such as food, clothing, shelter, light & fuel man earns money and spends his resource...
Effect of Integrated Weed Management and Balanced Fertilization on Weed Dynamics in Coriander (Coriandrum Sativum L)
A field experiment was conducted at Instructional Farm, Rajasthan College of Agriculture, Udaipur (Rajasthan) to determine the weed dynamics, in coriander and their effect on seed yield. Pooled analysis of two year data...
Cultural and Morphological Variability of Alternaria Lini Isolates Causing Blight of Linseed
Alternaria lini causes blight of linseed in India. The leaves showing typical symptoms of Alternaria blight, in linseed collected from different part of country and characterized for cultural, morphological, pathogenic a...
Effect of Pelletization with Bentonite on Emergence of Carrot Seeds
Many vegetable seeds are small, light and irregular in shape and therefore, it is difficult to plant them precisely. Sowing these problematic seeds with protective layers of coatings may be the solution to ensure its saf...