Effect of Chemotherapy on Zinc, Copper, Vitamin D Levels and Inflammatory Marker in Adult Acute Lymphoblastic Leukemia
Journal Title: Journal of Nutrition and Food Security - Year 2017, Vol 2, Issue 2
Abstract
Background: In acute lymphoblastic leukemia (ALL) the bone marrow loses its ability in the differentiation and maturation of blood cells at different stages. Zinc and copper are important co-factors for several enzymes and play an important role in maintenance of DNA integrity. Changes in serum levels of zinc and copper have been found in lymphoproliferative disorders. In the present study, the aim was to compare serum levels of zinc, copper, vitamin D, and inflammatory markers after eight courses of chemotherapy. Methods: Participants of this study included 30 ALL patients in the age range of 15 to 65 years. A 10 mL blood sample was taken before and after eight courses of chemotherapy. The concentration of Zinc, Copper, hs-CRP, vitamin D and malondialdehyde (MDA) were measured. Results: There was a significant increase in serum zinc (121.7 ± 18.05 µg/dL before chemotherapy and 156.6 ± 25.00 µg/dL after chemotherapy) and a significant decrease in serum copper (661.9 ± 190.1 µg/dL before chemotherapy and 402.2 ± 93.5 µg/dL after chemotherapy) and a significant decrease in Malondialdehyde and serum vitamin D were observwd. Further, no significant differences were observed in hs-CRP after chemotherapy. Conclusion: Results showed that chemotherapy could decrease the burden of disease by increasing serum zinc and decreasing serum copper.
Authors and Affiliations
Camellia Akhgarjand, Kurosh Djafarian, Hamid Rezvani, Azargashb Eznollah, Mohammadreza Vafa
Keywords
Related Articles
- EP ID EP203554
- DOI -
- Views 109
- Downloads 0
Survey of Synergistic Effect of L-carnitine with Glutamine on Body Composition and Dietary Intake in Soccer Players: A Double-blind, Randomized Clinical Trial
Background: The present study was conducted to investigate the possible effects of L-carnitine and glutamine and their synergistic effects on male soccer athletes. Methods: 28 male soccer players (21.1 ± 0.7 y) were enro...
Effects of Paleolithic Diet on Glucose Control in Adults: A Systematic Review and Meta-analysis of Controlled Clinical Trials
Background: Although the results were conflicting, the Paleolithic diet (PD) was proposed to be effective in improvement of metabolic status. We aimed to conduct a systematic review and meta-analysis on the randomized co...
Effect of Chemotherapy on Zinc, Copper, Vitamin D Levels and Inflammatory Marker in Adult Acute Lymphoblastic Leukemia
Background: In acute lymphoblastic leukemia (ALL) the bone marrow loses its ability in the differentiation and maturation of blood cells at different stages. Zinc and copper are important co-factors for several enzymes a...
Combined Effect of Chitosan-Based Edible Film Containing Oregano Essential Oil on the Shelf-Life Extension of Fresh Chicken Meat
Background: The aim of this study was to investigate the effects of chitosan coatings, oregano essential oil, and their combination on microbial quality of chicken fillet during 12 days in refrigerator temperature. Metho...
Household’s Food Consumption Profile during Agricultural Mitigation Period: Burkina Faso Centre-West Region Case
Background: Simplified and reliable tools for individual and household diet quality assessment have been found helpful to reduce cost of the dietary survey. The main objective of this study was to determine the household...