Effect of Chitosan on sustained release of chlorhexidine –an in vitro study
Journal Title: Journal of Dental Specialities - Year 2016, Vol 4, Issue 1
Abstract
Introduction: The aim of the study was to evaluate the sustained release effect of 2% chlorhexidine and its combination with 2% chitosan, in vitro. Method: The sustained release effect of chlorhexidine and its combination with chitosan was determined using a UV spectrophotometer. Results: UV spectrophotometer analysis for the sustained release of chlorhexidine showed that almost 100% of chlorhexidine was released within 4 hours. However when chlorhexidine was combined with chitosan, only 59% of chlorhexidine release was observed even at 24 hours. Conclusion: The percentage drug release of chlorhexidine was almost half when used in combination with chitosan, thus indicating the sustained release property of chitosan.
Authors and Affiliations
Shubhra Malik, Sonali Taneja, Rupali Chadha, Manju Kumari
Keywords
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