Effect of Chromolaena odorata leaf extract on haematological profiles in Salmonellae typhi infested Wistar rats
Journal Title: Journal of Research in Biology - Year 2013, Vol 3, Issue 3
Abstract
Haematological indices provide an insight about the internal environment of a given organism. In this present study, the possible anti-haemototxic effect of Chromolaena odorata on Salmonellae typhi – induced haematotoxicity in rats were investigated. The experimental animals were divided into three groups. Group A received only food and water (control). Group B and C received in addition to food and water, single dose of stock Salmonellae typhi at a dose of 106cfu/ml. The animals in group B and C were allowed to be infected with Salmonellae typhi for 7 days and confirmed by widal test, after which group C was treated with 750mg/kg body weight/ day ethanolic extract of Chromolaena odorata for 10 days. The result showed a significant (p < 0.05) decrease in Red Blood Cells (RBC) count, packed cell volume (PCV), haemoglobin (Hb), mean corpuscular haemoglobin (MCH), Mean Corpuscular haemoglobin Concentration (MCHC), neutrophil and increase in platelet, total White Blood Cell (WBC) and lymphocytes in animals infected with Salmonellae typhi when compared to the control non-infected group. Treatment of animals in group C with ethanolic extract of Chromolaena odorata showed a significant (P < 0.05) increase in mean values of RBC count, PCV, Hb, MCH, MCV, MCHC and decrease in platelets, WBC and lymphocytes when compared to the group infested with Salmonellae typhi only. The results above suggest the anti-haematotoxic potential of ethanolic extract of Chromolaena odorata in Salmonellae typhi infested rats
Authors and Affiliations
Nwankpa P, Ezekwe As, Ibegbulem CO, Egwurugwu JN
Keywords
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