Effect of Chronic Consumption of Calabash Chalk Diet (Nzu) On Locomotor Activities in Swiss White Mice.
Journal Title: Journal of Medical and Dental Science Research (Quest Journals JMDSR) - Year 2018, Vol 5, Issue 3
Abstract
There are safety concerns as regards the consumption of Calabash chalk which is common practice in some localities in Africa and Asia. The effect of chronic Consumption of calabash chalk on locomotive activities in the Swiss White Mice was carried out using the Open Field Maze Test (OFM).The OFM provided simultaneous assessment of locomotion, exploration and anxiety using parameters such as recording of number of line crossing, frequency of walling, frequency of rearing and frequency of center square entry. A total of forty-five (45) healthy Swiss White Mice (SWM) randomly divided into groups A, B and C; were used for this work. Group A, which served as a control, was fed the normal rodent chow and water ad libitum while group B and C were fed with low dose (LD) and had high dose (HD) of the Calabash Chalk extracts mixed with rodent chow respectively. The result of the OFM showed a general reduction in locomotor activities among animals in the test groups following chronic consumption of calabash chalk diet. This may be linked to the possible neurotoxic or arthropathic effect following long chronic exposure to lead found which is a component of calabash chalk .It is imperative that caution be exercised in the human consumption of calabash chalk.
Authors and Affiliations
Owhorji, B. I, Nwankwo, A. A;, Iheukwumere, C. B, AkunnehWariso C;, Uket J. M
Keywords
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Effect of Chronic Consumption of Calabash Chalk Diet (Nzu) On Locomotor Activities in Swiss White Mice.
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