Effect of Cichorium intybus L. extracts and Kelussia oderatassima Mozaff. essential oil on toxic of organophosphouros insecticides in RAT
Journal Title: Journal of Herbal Drugs - Year 2010, Vol 1, Issue 2
Abstract
Background & Aim: Organophosphates are frequently used as insecticides in households, in agricultural areas and veterinary, thus posing a risk for accidental dermal exposure or through inhalation. Acute organophosphate poisoning causes thousands of human mortalities each year in developing countries. Material & Methods: This study carried out to study an antitoxic effect of endemic Iranian medicinal plants agent against organophosphorus on rats. In order, anti-toxic effects of Cichorium intybus L. root ethanol extract and Kelussia oderatassima Mozaff. leaves essential oil on liver and kidney rat. This is an experimental study in 18 Wistar rats were randomly into 6 groups. After 24 hr fasting, normal saline was given to the first group, two and three groups received 200 and 400 mg/kg Cichorium intybus extract, four and five groups received 200 and 400 mg/kg Kelussia oderatassima essential oil and six groups received standard drug (Phenobarbital). Results & Discussion: The histopathological observation indicated that the lowest necrosis in kidney was group received 200 mg/kg Kelussia oderatassima essential oil and highest necrosis in kidney was groups received 200 and 400 mg/kg Cichorium intybus extract and standard drug. The histopathological observation indicated that standard drug and groups received 400 mg/kg Cichorium intybus extract and 200 mg/kg Kelussia oderatassima essential oil may protect liver against acute hepatotoxicity induced by Organophosphate insecticide. Also the highest of increased weight rats revealed group received 200 mg/kg Kelussia oderatassima essential oil. Conclusion: The results show that Kelussia oderatassima essential oil an antitoxic effect against organophosphrus on at.
Authors and Affiliations
Abdollah Ghasemi Pirbalouti; Ali Shahvali; Firozeh Saghaee; Shahrzad Azizi; Behzad Hamedi; Lohraseb Shahgholian
Keywords
Related Articles
- EP ID EP23313
- DOI -
- Views 792
- Downloads 126
Effect of seasonal variation on essential oil yield, and morpho-physiological properties of Achillea filipendulina Lam
Background & Aim: Achillea filipendulina is one of the most important species of the family Asteraceae and, it considered as one of the most valuable medicinal and ornamental plants. Environmental factors affected on qua...
Anti-ulcerogenic activity of stem extract and fractions of Homalium letestui
Background & Aim: Homalium letestui Pellegr (Flacourtiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties...
Evaluation of anti-leishmanial efficacy by extract of Artemisia auchery Boiss. on Leishmania major in Balb/c
Background & Aim: Cutaneous infection caused by protozoa the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries including Middle East, Africa and Latin America. In the abs...
Effect of Different Drying Methods on Some Biochemical Properties of Iranian Ox-tongue (Echium amoenum Fisch. & Mey.)
Background & Aim: Iranian ox-tongue (Echium amoenum Fisch. & Mey.) is an endemic Iranian medicinal plant belongs to Boraginaceae family. The violet-blue petals of this plant have been used in traditional medicine. Dry...
Chemical composition and antimicrobial activity of essential oil of Salvia officinalis L. and Salvia virgata Jacq
Background & Aim: The genus Salvia (commonly known as sage) is a broad genus belonging to the family Lamiaceae. This study is aimed at assessing the essential oil composition and antimicrobial activities of two Salvia...