Effect of cirrhosis at baseline on the outcome of type 1 autoimmune hepatitis
Journal Title: Annals of Hepatology - Year 2012, Vol 11, Issue 1
Abstract
Material and methods. With the aim of analyzing the influence of presence of cirrhosis at baseline on the outcome, we revised the evolution of a cohort of patients with type 1 autoimmune hepatitis, prospectively followed at a single hospital. 139 patients (113 females, 26 males), median age 45.7 years, interquartile range 13-59 years, were followed-up for a median period of 58 months (interquartile range 27-106). Results. At baseline, 55 patients had cirrhosis and they were significantly older, had lower prothrombin activity and serum albumin than patients without cirrhosis. In contrast, patients without cirrhosis had significantly higher bilirubin, AST and ALT levels at diagnosis time. There was no significant difference in the follow-up time between patients with and without cirrhosis at baseline and either in the percentage of patients receiving immunosupresor treatment (80 vs. 91%, respectively) or in the response to therapy (complete response in 82 vs. 95%, respectively). However, patients with cirrhosis had a significantly lower probability of remaining free of cirrhosis complications (49.1% at 102 months, 95%CI, 35.5-67.9% vs. 86.7%, 95%CI, 77.1%-97.5%, respectively) (p = 0.0000) and a significantly lower overall survival at 120 months (67.1%, 95%CI, 51.3-87.6 vs. 94.4%, 95%CI, 86.9-100%, respectively) (p = 0.003) than those without cirrhosis at presentation. Conclusion. Patients with type 1 autoimmune hepatitis and cirrhosis at presentation have a lower survival than those without cirrhosis despite a similar response to treatment.
Authors and Affiliations
Graciela Landeira, Silvia Morise, Eduardo Fassio, Margarita Ramonet, Estela Álvarez, Patricia Caglio, Cristina Longo, Nora Domínguez
Keywords
Related Articles
- EP ID EP78106
- DOI -
- Views 131
- Downloads 0
Herbal hepatotoxicity and WHO global introspection method
Herbal hepatotoxicity is a rare but highly disputed disease because numerous confounding variables may complicate accurate causality assessment. Case evaluation is even more difficult when the WHO global introspection me...
Factors associated with spontaneous HBsAg clearance in chronic hepatitis B patients followed at a university hospital
Introduction. Few studies have evaluated the factors involved in the spontaneous HBsAg seroclearance in patients with chronic hepatitis B (HBV) followed up on a long-term basis from areas with a low prevalence of HBV inf...
Predictive role BLVRA mRNA expression in hepatocellular cancer
Introduction and aim. Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor. It is primarily causedby hepatic cirrhosis or chronic viral hepatitis. Hepatic carcinogenesis is associated with inc...
Effects of TIPS on global end-diastolic volume and cardiac output and renal resistive index in ICU patients with advanced alcoholic cirrhosis
The transjugular porto-systemic stent-shunt (TIPS) reduces portal pressure in cirrhotic patients and is used as a nonsurgical treatment for refractory ascites, recurrent variceal hemorrhage or hepatorenal syndrome. There...
Diagnostic value of fibronectin discriminant score for predicting liver fibrosis stages in chronic hepatitis C virus patients
[b]Background[/b]. Several noninvasive predictive models were developed to substitute liver biopsy for fibrosis assessment. [b]Aim[/b]. To evaluate the diagnostic value of fibronectin which reflect extracellular matrix m...