Effect of cobalt nano-particles on serum biochemical and histopathological changes in liver and kidney of lambs
Journal Title: Iranian Journal of Veterinary Science and Technology (IJVST) - Year 2013, Vol 5, Issue 2
Abstract
Cobalt is an essential co-factor in red blood cell production and function and its deficiency may produce clinical signs in sheep. Thus, present study was designed to evaluate the effect of cobalt nano-particles on serum biochemical factors and histopathological changes in liver and kidnies of lambs. Study was carried out in 3 groups of lambs (4 lambs per group). One group of lambs was kept as control group. Second and third group respectively received cobalt nano-particles and conventional cobalt chloride suspension daily for a period 25 day. Blood sample and then serum was collected before and at the end of study. Activity of ALT, AST, ALP and level of BUN, creatinine and vitamin B12 were measured in serum of lambs. Tissue sections of liver and kidney were stained with hematoxylin and eosin and examined by light microscopy. Activity of ALT, BUN and vitamin B12 was significantly increased by cobalt nano-particles and conventional cobalt chloride. Fatty change of hepatocytes occured by conventional cobalt and granulomatous hepatitis, focal necrosis of hepatocytes and degeneration of hepatocytes by the nano cobalt was identified in liver. There were not any significant lesions and alteration in the kidnies of treated groups. Thus, cobalt nano-particles have similar effect to conventional cobalt for using in sheep with cobalt deficiency.
Authors and Affiliations
Seyed Morteza Ghoreishi,Hossein Najafzadeh,Babak Mohammadian,Eisa Rahimi,Mohammad Reza Afzalzadeh,Mohammad Kazemi Varnamkhasti,Hadi Ganjeali Darani,,
Keywords
Related Articles
- EP ID EP722493
- DOI -
- Views 36
- Downloads 1
The hematological profile changes in Saanen goat kids from birth to 3 months of age
This study performed to determine hematological parameters in Saanen goatsâ kids from birth until 3 months of age. The whole blood specimens were collected from 20 clinically healthy goat kids (15 females and 5 males)....
Effect of follicle stimulating hormone and testosterone on viability rate of cryopreserved spermatogonial stem cell after thawing
Stem cells are generally defined as clonogenic cells capable of both self-renewal and differentiation. Probably the best method for long-term preservation of spermatogonial stem cells is cryopreservation. In this study,...
Isolation and culturing myogenic satellite cells from ovine skeletal muscle
Sheep satellite cells more than satellite cells of the rat and mouse are similar to human satellite cells. These cells are widely used in the modeling and treatment of diseases like heart insufficiency, neurological dise...
Detection of Ciprofloxacin resistance genes in Escherichia coli isolated from dogs with urinary tract infections
This research was performed on uropathogenic Escherichia coli (E. coli) isolates and established the genes of resistance to ciprofloxacin between the isolates. A total of one hundred and three urine samples were tested f...
Isolation, Antimicrobial Resistance, and Virulence Genes of Thermophilic Campylobacter Species from Backyard Ducks in Amol, Northern Iran
Domestic poultry are considered natural reservoirs for the transmission of Campylobacter spp., mainly C. jejuni and C. coli, to other birds and humans. This study aimed to determine the Campylobacter infection status in...