EFFECT OF COCCULUS HIRSUTUS LEAVES EXTRACT ON FREUNDS COMPLETE ADJUVANT AND FORMALDEHYDE INDUCED ARTHRITIS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
Cocculus hirsutus Linn (Menispermaceae) leaves known as chilahinta in ayurveda and kattukudi in sidha is an important medicinal plant belonging to family menispermaceae .the leaves are used to treat several disease like eczema, dysentery and urinary problem . In the present study ethanolic extract of Cocculus hirsutus leaves was used for investigation of antiarthritic activity by using freunds complete adjuvant and formaldehyde as inducer. Animals treated with ethanolic extract of cocculus hirsutus leaves at the dose 200mg/kg and 400mg/kg showed significant decrease in arthritis in all models. The results suggests that the extract at 400mg/kg showed significant reduction (p<0.001) in paw diameter when compared with control group of animal. These findings indicate that cocculus hisutus leaves extract shows significant antiarthritic activity.
Authors and Affiliations
Rakesh Tirkey , Prashant Tiwari
Keywords
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