Effect of cyclophosphamide in histological features of cerebellum in chick embryo
Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2016, Vol 4, Issue 2
Abstract
Cyclophosphamide is an Alkylating Agent and it comes under the category of Nitrogen Mustards, which is used commonly in the treatment different types of Cancers or Carcinomas or Neoplasms (Goodman and Gilman 9th edition 1996).It was synthesized and Introduced in the year 1854 and its properties were elaborately observed and described by 1887. Cyclophosphamide is administered in the treatment of Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemias, Hodgkin’s Lymphoma, Non-Hodgkin’s, Lymphoma, Multiple Myeloma, Neuroblastoma, Breast Cancer etc. It is also a potent Immuno Suppressive Drug. It has been used for the Control of Organ Rejection after Transplantation, Wegner’s Granulamatosis, Rheumatoid Arthritis, Nephrotic Syndrome in Children. In the present study fertilized eggs were administered with Cyclophosphamide and histological features of cerebellum were studied after 20 days. Cyclophosphamide cytotoxicity results in reduction of multiplication of cell activity associated with malformations and embryonic death. Injection of the drug causes decrease of mitotic activity which produces deformities.
Authors and Affiliations
Shabana Sultana
Keywords
Related Articles
- EP ID EP419789
- DOI -
- Views 35
- Downloads 0
The relationship between alcohol consumption, liver enzymes and high density lipoprotein cholesterol in a general population in Punjab
Background Health problems related to lifestyle and behavior are increasingly common in modern societies. Recent studies have indicated that the common liver enzymes, gamma-glutamyltransferase (GGT), alanine aminotransfe...
Diagnostic utility of fine needle aspiration cytology in superficial lymphadenopathy in pediatric patients
Background Lymphadenopathy is one of the common clinical presentations in outdoor patient department, especially in pediatric age group. Fine needle aspiration cytology (FNAC) of the lymph nodes has become an integral pa...
Effect of mat and swiss ball based pilates exercises in s
Background Non-Specific Low Back Pain is a major health problem worldwide. Interventions based on exercises have been the most commonly used treatments for students with this condition. Over the past few years, the Pilat...
A case presentation on acute ischemic stroke
Background information A 52 years old male patient has been admitted in the hospital with the chief complaints of slurred speech, weakness in right extremities and he does have a medical history of hypertension, diabetes...
A review on concept of Body Donation and Ayurveda Prospective
Body donation is the donation of whole body after death for medical research and education purpose.The body donation is honourable and gracious act which helps society in many ways. Voluntary Body Donation is a program w...