Effect of Cytomegalovirus and Diabetes Mellitus on the Cytokine Profile of Cellular Immunity in Tuberculosis Patients
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 3
Abstract
Aims: This study aims to investigate the effect of cytomegalovirus (CMV) and diabetes mellitus (DM) on the cell-mediated immunity against TB represented by cytokine profile Study Design: Case control study. Place and Duration of Study: This study was carried out in Specialized Chest and Respiratory Center in Baghdad, Iraq and Department of Medical Microbiology-College of Medicine -Babylon university Hilla-Iraq, the period of study was October 2012 to January 2013. Methodology: This study was applied on 70 TB patients .It involved also 30 apparently healthy control. The patients consists of 43 males and 27 females with age range 8-76 years old, 29 of them were diabetic .Blood samples were collected from patients and controls to estimate the immune parameters interferon-gamma (IFN-γ) and interleukin -2(IL-2 )as , and anti –CMV IgG antibodies by enzyme linked immunosorbent assay (ELISA). Results: The immune parameters showed that there is no significant difference in the mean serum concentration between the patients and control groups for IFN-γ and IL-2 (P=0.05), while there was a significant increase in the mean serum concentration of anti-CMV IgG between study groups (P≤0.001). The study also showed that there is a significant decrease in the mean serum concentration of IL-2 and IFN-γ between diabetic TB patients comparing with those non-diabetic TB patients where p values were 0.008 and 0.024 respectively. Conclusion: Both CMV and diabetes mellitus have a role in the suppression of cellular immunity in TB patients.
Authors and Affiliations
Mohammed A. K. AL-Saadi, Jawad K. AL-Khafaji, Nazar A. Sheriff
Keywords
Related Articles
- EP ID EP348707
- DOI 10.9734/BJMMR/2014/6671
- Views 54
- Downloads 0
Fatigue Syndrome in Multiple Sclerosis
Background: Multiple sclerosis (ms) is a chronic and often debilitating disease that mostly affects young people who constitute the active part of community. The incidence of the disease has increased in recent years. Fa...
Gingival Depigmentation Using Lasers: A Literature Review
Background: Gingival hyperpigmentation usually occurs due to the abnormal accumulation of melanin in the gingival tissue and confers a dark appearance to the gingiva. Gingival hyperpigmentation often compromises smile es...
Dietary Diversity is a Predictor of Acute Malnutrition in Rural but Not in Urban Settings: Evidence from Ghana
Aims: To document the relationships between child dietary diversity and acute malnutrition (wasting) in urban and rural Ghana, controlling for maternal, child and household socio-demographic characteristics. Study Design...
Etiologic Evaluation of 1012 Patients Admitted with Thrombocytopenia
Introduction: Thrombocytopenia is the situation where the number of thrombocytes is less than 150.000/ µL. This may result due to decreased thrombocyte production, increase in the destruction of thrombocytes and differen...
A Non-healing Ulcer with Unilateral Facial Palsy
Introduction: Oral cavity is a hub for millions of microorganisms which are non pathogenic, but in immunocompromised states, plethora of diseases emerge which may be the most rarest and fatal. Mucormycosis has emerged as...