Effect of Device Design and Formulation on the In Vitro Comparability for Multi-Unit Dose Dry Powder Inhalers
Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 5
Abstract
The online version of this article (doi:10.1208/s12248-015-9775-z) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Jagdeep Shur, Bhawana Saluja, Sau Lee, James Tibbatts, Robert Price
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Analytical ultracentrifugation (AUC) and field flow fractionation (FFF) are 2 important biophysical methods for measuring protein aggregates. Both methods can separate protein monomer from its aggregate forms under a bro...
Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development
The in vivo metabolic clearance in human has been successfully predicted by using in vitro data of metabolic stability in cryopreserved preparations of human hepatocytes. In the predictions by human hepatocytes, the syst...
Determination of the Dominant Arachidonic Acid Cytochrome P450 Monooxygenases in Rat Heart, Lung, Kidney, and Liver: Protein Expression and Metabolite Kinetics
Cytochrome P450 (P450)-derived arachidonic acid (AA) metabolites serve pivotal physiological roles. Therefore, it is important to determine the dominant P450 AA monooxygenases in different organs. We investigated the P45...
Are Physiologically Based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site
The online version of this article (doi:10.1208/s12248-015-9796-7) contains supplementary material, which is available to authorized users.
Pharmacokinetic Interactions for Drugs with a Long Half-Life—Evidence for the Need of Model-Based Analysis
The online version of this article (doi:10.1208/s12248-015-9829-2) contains supplementary material, which is available to authorized users.