Effect of Dexmeditomidine and Clonidine as Spinal Adjuvant in TURP – A Comparative Study
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 8
Abstract
Background: The standard anaesthetic technique for TURP (Transurethral Resection of Prostate) is subarachnoid block. Bupivacaine is the local anaesthetic drug used to achieve the subarachnoid block. Adjuvants are used to enhance analgesia, to lower the bupivacaine dosage and to reduce the dose dependent side effects. Effects of Clonidine and Dexmedetomidine on subarachnoid block in TURP are compared in this study. Aim: Aim of this study is to compare Dexmedetomidine and Clonidine as spinal adjuvant with Bupivacaine in TURP surgeries. Settings and Design: This is a randomized double blinded study conducted in 60 patients of ASA I and II undergoing elective TURP surgeries. Patients were allocated in three groups. Group A (Bupivacaine + sterile normal saline as placibo) Group B (Bupivacaine + Clonindine 30µg) Group C (Bupivacaine + Dexmedetomidine 5µg). Materials and Methods: After getting the ethical committee approval the study was conducted in 60 patients undergoing elective TURP surgeries. It was a double blinded study in which patients were randomly allocated into three groups by using the computer based randomization Group A- Inj. 0.5% Bupivacaine 2.0 cc + Normal saline 0.5cc = 2.5cc ,Group B (clonidine)Inj. 0.5% Bupivacaine 2.0 cc + Inj.Clonidine (30µg) 0.5cc = 2.5 cc ,Group C (dex) Inj. Bupivacaine 2.0 cc+ Inj. Dexmedetomidine (5µg) 0.5cc= 2.5 . Statistical Analysis Used: Data analysis was done with Epidemiological Information Package (EPI 2008). ANNOVA t test was used to test the significance of difference between quantitative variables. Results: Time to peak sensory level and time for Modified Bromage scale – 3 motor block were earlier and statistically significant in Dexmeditomidine group. Time for 2 segment regression, time to regress Modified Bromage 0, time to regress to S1 level, rescue analgesia duration were significantly more in Dexmeditomidine group Conclusion: Adding 30µg Clonidine or 5µg Dexmedetomidine to 10mg of Bupivacaine significantly prolongs the duration of post operative analgesia when compared to Bupivacaine alone in elective transurethral resection of prostate (TURP) surgeries, without any side effect.
Authors and Affiliations
Arulraj Panchatcharam
Keywords
Related Articles
- EP ID EP529068
- DOI -
- Views 32
- Downloads 0
Analysis of Cases of Gestational Hypertension in Pregnant Women: A Clinical Study
Background: Pregnancy is associated with many complications. Among all complications, hypertension is the leading causes of maternal and perinatal deaths in developing countries. Hypertensive disorders of pregnancy rank...
Dermato-Epidemiological Profile and HIV Seropositivity among Male Patients with Herpes Zoster
Background: Herpes zoster represents reactivation of the latent varicella-zoster virus in the sensory ganglia and forms a small subset of patients attending skin OPD. The study was conducted in Herpes zoster patients to...
Effect of Antihypertensive Drugs on Glucose Tolerance and Lipid Profile in Hypertensives With and Without Diabetes Mellitus
Diabetes is the most common endocrine disease. It is a heterogeneous primary disorder of carbohydrate metabolism with multiple etiologic factors that generally involve absolute or relative insulin deficiency or insulin r...
Study of Psychosocial Factors in Young and Elderly Asthmatics
Introduction: Asthma affects the children, young, as well as elderly populations. Psychosocial factors have been extensively studied in children and younger asthmatics. They can have a significant impact in the elderly a...
Pemphigus Vegetans of Hallopeau Type
Pemphigus vegetans is a rare variant of pemphigus vulgaris that is characterized by vegetating lesions primarily in the flexures. A 49 year old male having chronic kidney disease had a vegetating growth of groin, periana...