EFFECT OF DIABETIC AUTONOMIC NEUROPATHY ON DETERMINANTS OF MYOCARDIAL OXYGEN DEMAND
Journal Title: International Journal of Basic and Applied Physiology - Year 2014, Vol 3, Issue 1
Abstract
Background : Resting myocardial oxygen demand determinants are less studied in diabetic autonomic neuropathy patients. Objective: An insight into the determinants of myocardial oxygen demand in diabetic autonomic neuropathy patients may explain sudden adverse cardiovascular events in such patients. Methods: Case control study (n=60) was done on forty age matched (40-60 yr) type 2 diabetics with/ without diabetic cardiac autonomic neuropathy and twenty controls for myocardial oxygen demand determinants (heart rate, rate pressure product, systolic blood pressure) at rest. Results: Results demonstrated (unpaired ‘t’ – test, ‘SPSS’ software) that all variables were significantly increased in neuropathy patients compared to controls (p<0.05) (95%CI). Heart rate, rate pressure product significantly increased in neuropathy patients compared to non neuropathy counterparts (p<0.05) (95%CI). Significantly increased heart rate, rate pressure product in non neuropathy patients compared to controls (p<0.05)(95%CI). Resting rate pressure product highest (>12) in neuropathy patients. Conclusion: Diabetic cardiac autonomic neuropathy significantly increases all determinants of resting myocardial oxygen demand contributing to exaggerated ischemic episodes and increased mortality even at rest
Authors and Affiliations
Rishu Segan, Lily Walia, Naveen Mittal
Keywords
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