Effect of diazepam and chlorpromazine on proliferative activity and vascular endothelial growth factor (VEGF) secretion from cultured endothelial HECa10 cells in vitro.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 5
Abstract
Diazepam and chlorpromazine - psychotropic agents widely used for the amelioration of anxiety, depression, and psychosis, have been found to affect cell proliferation. We have checked whether these drugs influence proliferation of endothelial cells and probably angiogenesis process. We have studied the effect of diazepam and chlorpromazine on proliferative activity and vascular endothelial growth factor (VEGF) release from murine endothelial HECa10 cells cultured in vitro. In conclusion, diazepam at concentration of 10(-4)M had inhibitory action on the proliferation of endothelial cells in cultures. Chlorpromazine at concentrations from 10(-7) to 10(-4)M diminished the proliferative activity and secretion of VEGF into supernatants of cultured cells.
Authors and Affiliations
Beata Misztal-Dethloff, Henryk Stępień, Jan Komorowski
Keywords
Related Articles
- EP ID EP118267
- DOI -
- Views 99
- Downloads 0
Medium supplementation with zinc enables detection of imipramine-induced adaptation in glycine/NMDA receptors labeled with [3H]L-689,560.
Antidepressant drugs after chronic administration induce adaptive changes in the NMDA receptor complex. Radioligand-receptorbinding studies using [3H]5,7-dichlorokynurenic acid demonstrated a "down-regulation" of the gly...
Protective effects of histamine H(3)-receptor ligands in schizophrenic behaviors in experimental models.
Schizophrenia (SCZ) afflicts around 1% of the world's population with characteristic symptoms such as hallucinations, delusions, and cognitive disorders. Several experimental studies in the past have indicted brain hista...
Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels.
The aim of the present study was to investigate the role of GABAergic and nitriergic modulation in the antianxiety effect of thymoquinone, a major constituent of Nigella sativa, in mice under unstressed and stressed cond...
NSAIDs and cardiovascular disease: transducing human pharmacology results into clinical read-outs in the general population.
Traditional (t) non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase (COX)-2 inhibitors (coxibs) are important and efficacious drugs for the management of musculoskeletal symptoms. These drugs have...
A carbon monoxide-releasing molecule (CORM-3) attenuates lipopolysaccharide- and interferon-gamma-induced inflammation in microglia.
The development of carbon monoxide-releasing molecules (CO-RMs) in recent years helped to shed more light on the diverse range of anti-inflammatory and cytoprotective activities of CO gas. In this study, we examined the...