Effect of Ehretia microphylla on the blood cholesterol and weight of ICR mice (Mus musculus)
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 7
Abstract
Background: Simvastatin has been widely used in controlling blood cholesterol levels and weight; however, side effects such as muscle pain, muscle damage, liver damage, and hyperglycemia may occur. Studies have shown that intake of herbal medicines may be supplemental and may even be more effective than medicines available in the market. Aims and Objectives: The objectives of this study are to assess the effects of administration of aqueous leaf extract of Ehretia microphylla in ICR mice on blood cholesterol levels and weight. Materials and Methods: A total of 35 ICR mice were designated into five groups which are the negative control group, positive control group, low dose, mid dose, and high dose. All groups were fed with lard-coated feeds to increase blood cholesterol level and weight. The positive control group was treated with 2.0 ml of simvastatin, while the negative control remained untreated. The treatments, namely, the low dose, mid dose, and high dose were treated with 250 mg/kg, 500 mg/kg, and 1000 mg/kg of the E. microphylla extract, respectively. Results: After 14 days of treatment, statistical analysis indicated that the E. microphylla extract had anticholesterolemic effect. There was a significant difference in the high-dose group. There was also no significant difference observed in the other groups, namely, the low dose and the mid dose. Furthermore, the positive group treated with simvastatin had a significantly lowered cholesterol level compared to the high-dose group. There are inconclusive results on the effect of E. microphylla on weight. Conclusion: E. microphylla has anti-hypercholesterolemic effects, which may be attributed to the different phytochemicals present in it.
Authors and Affiliations
Daniella Marie Cagampan, Kathlyn Airielle Lacuata, Michael B , Ples, Rodel Jonathan S Vitor II
Keywords
Related Articles
- EP ID EP491290
- DOI 10.5455/njppp.2018.8.0206804032018
- Views 70
- Downloads 0
Correlation of pain sensitivity and sweet taste in healthy male adults
Background: Many studies have established a relationship between the administration of small amounts of sweet - tasting (sucrose) solution to the tongue and analgesia in rat pups and human infants. Hence, we inten...
Comparative study of anthropometric parameters in diabetic and non-diabetic human beings
Background: Diabetes mellitus is a group of metabolic disorders sharing the common underlying feature of hyperglycemia. Peripheral resistance to insulin is a prominent feature of diabetes. Skeletal muscle is the primary...
Effect of family history of hypertension on the autonomic nervous system in normotensive individuals
Background: Hypertension is a major public health problem, which usually has a silent modus operandi. It is the outcome of a complex interaction between genetic and environmental factors. Aims and Objective: The aim of t...
Mechanism of resistance to tyrosine kinase inhibitors - A case report and review
This report aims to assess the viability of various challenging approaches such as tyrosine kinase inhibitors (TKIs) therapy, chemotherapy, and stem cell transplantation in patients with chronic myeloid leukemia (CML), e...
Knowledge, attitude, and practices toward Jan Aushadhi scheme
Background: Increased health-care expenses are a major concern in a country like ours where economic conditions are on the lower side. The Government of India to control the increased health-care expenses launched the Ja...