Effect of Erythropoietin on Fasting Blood Glucose of Diabetic Albino Rats, at 3 Different Doses (EPO 40,100 & 300 IU/Kg)
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 2
Abstract
Background: Previously some studies have implicated erythropoietin (EPO) signalling in the regulation of glucose metabolism. Whether EPO can be used treat diabetes and the exact underlying mechanism remain to be elucidated. The present study aimed to investigate whether EPO affects glucose levels, and the underlying mechanisms, in experimental diabetic rats. The effects of EPO (40, 100 & 300 IU/kg three times a week for 4 weeks) on glucose metabolism in streptozotocin, nicotinamide induced diabetic albino rats was studied here. Methods: 30 albino rats were taken and divided into five groups of six rats in each group. The groups were normal control, diabetic control, diabetic rats treated with EPO in doses of 40,100 and 300 IU/Kg in the last three groups. Diabetes was induced in four groups by intraperitoneal injection of streptozotocin in the dose of 60 mg/kg. To have an ideal type 2 diabetes model nicotinamide was administered 120 mg/ kg intraperitoneally fifteen minutes before streptozotocin administration. After successful induction of diabetes EPO (40,100 and 300 IU/kg, three times a week) was given to the respective groups for a period of 4 weeks. Fasting blood glucose was estimated on day 0, 7, 14, 21 and 28 of treatment. Results: In this study EPO showed significant anti-hyperglycaemic effect in all the three groups receiving EPO (p<0.05 in all 3 groups). Conclusions: From this study we can conclude that EPO has a marked anti-hyperglycaemic effect and the effect is dose dependent. Further studies are required at different doses to establish the optimum dose for its use as an anti-diabetic drug and to alleviate or avoid the adverse effects before it can be used for the treatment of diabetes or its complications.
Authors and Affiliations
Vineet Kumar
Keywords
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