Effect of Estradiol Valerate on Serum Biochemical Profiles in Aged Female Albino Rats
Journal Title: Annual Research & Review in Biology - Year 2015, Vol 6, Issue 2
Abstract
Estradiol valerate is used for hormone replacement therapy because it contains the principal oestrogen hormone that is lost during the change of life. Progynova contains estradiol valerate, an ester of the endogenous female estrogen. The main aim of this study was to evaluate the serum profiles in estradiol valerate administered aged female rats. In the present study estradiol valerate (progynova tablets) administered orally at the dose of 8mg/Kg body weight/day to aged female rats for one week through oral gavages method. Significant decrease in serum lipids by administration alters lipid profiles favorably. The elevated levels of serum Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) in aged rats, indicates the necrosis in liver due to the lowered estrogens, which were reversed by estradiol valerate administration.
Authors and Affiliations
A. Lalithamma, C. Changamma
Keywords
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- EP ID EP353604
- DOI 10.9734/ARRB/2015/14749
- Views 84
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