Effect of Ethanol Extract of Curcuma Longa on Aspirin Induced Gastric Injury
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 3
Abstract
Objective: To study the Ulcer Index, gross morphology and histopathological pictures of effect of Ethanol extract of curcuma longa (CLE) on Aspirin induced gastric injuries. Method: After animal ethics committee approval, the effect of CLE was studied on ten groups of guinea pigs. Group I & 2 were given 1% carboxy methyl cellulose (CMC) & Aspirin 500 mg/kg in 1% CMC respectively. Group 3, 4,5,&,6 were given CLE 20,40, 80 &160mg/kg respectively in 1% CMC followed one hour after by Aspirin. Group 7,8 &9 were given CLE 20, 40 & 80mg/kg respectively. Group-10 received Ranitin 30mg/kg followed one hour after by Aspirin. Ulcer-Index was calculated and analysed statistically and the histopathology study of gastric mucosa was undertaken. Results: CLE up to 80mg/kg did not produce any gastric injury. Pretreatment with CLE 80mg/kg & 160mg/kg produced highly significant protection [P<0.001] against Aspirin induced gastric injuries & hemorrhages. Conclusion: Ethanol extract of curcuma longa prevents Aspirin Induced gastric injury
Authors and Affiliations
Dr Kali Prasad Pattnaik
Keywords
Related Articles
- EP ID EP281367
- DOI -
- Views 51
- Downloads 0
A Study of Clinical Profile of Empyema Thoracis Patients in Tartary care center at Agra
Background: Pleural infection is one of the oldest and most severe diseases. Prompt recognition of the development of empyema is crucial to successful treatment. Even with appropriate therapeutic attempts, mortality of p...
Comparison of Pre and Post Operative Corneal Astigmatism following Pterygium Excision and Conjunctival Autograft
Objective: To evaluate the effect of pterygium excision on pterygium induced corneal astigmatism Methods: Hospital based study conducted in a tertiary care centre in Western Maharashtra from August 2014 to March 2015. A...
Associated Maxillofacial Injuries in Patients with Severe brain Injuries: Institutional Study of Ateritiary Care Hospital
There is dearth of information in the literature regarding the relationship between head injuries and facial trauma in literature. The objective of our study was to study this important relationship. We evaluated 230 pat...
Impact of BCG Vaccination Status on Sputum Conversion Rate in New Sputum Positive cases of Pulmonary Tuberculosis
Objectives: Sputum conversion rates (SCR) at the end of intensive phase of treatment of pulmonary tuberculosis varies and knowledge of factors involved is, inadequate. It has been reported that presence of a BCG scar was...
Incidence and Risk Factors for Ventilator Associated Pneumonia in ICUS of Medical College Hospital Kottayam
Introduction: Ventilator Associated Pneumonia (VAP) is defined as pneumonia occurring more than 48 hours after initiation of intubation and mechanical ventilation. VAP continues to complicate the course of 8-28% of patie...