EFFECT OF ETHANOLIC AND ETHYLACETATE EXTRACT OF MERREMIA EMARGINATA (BURM.F) IN RHEUMATOID ARTHRITIS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 9
Abstract
The effect of alcoholic and ethyl acetate extracts of the whole plant of Merremia emarginata (Burm. F) Hallier f. on freund’s adjuvant induced arthritis was evaluated. The percentage of yield was found to be 18.7 and 10.6% for alcoholic and ethyl acetate extracts respectively. Both the extracts significantly (p <0.05) decrease the paw thickness at the end of 21 days treatment. Though in acute phase inflammation both of them show the same potency in chronic phase alcoholic extract exhibit more potency than the ethyl acetate extracts. At the end of the studies the alcoholic extract shows more pronounce effect as comparable to ethyl acetate extract. The phytochemical analysis reveals the presence of flavonoids, glycosides, phenols, carbohydrates and proteins in the extracts. This result support the folkore use of this plant against the inflammmatory conditions like arthritis.
Authors and Affiliations
Prabhu. Purushoth , P Pannerselvam. , S Selvakumari. , R Vijaykumar. , D Sivaraman
Keywords
Related Articles
- EP ID EP150986
- DOI -
- Views 72
- Downloads 0
FORMULATION AND EVALUATION OF MEFENAMIC ACID SOLID DISPERSIONS USING PEG-4000
Mefenamic acid (MA) solid Dispersions were prepared employing methanol as a common solvent using PEG-4000 as a drug carrier with two different techniques namely, melting method and solvent evaporation in varied ratios. T...
FORMULATION AND EVALUATION OF IRBESARTAN IMMEDIATE RELEASE TABLETS
Irbesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to the AT1 angiotensin II receptor. ACE inhibitor is used in treatment of hypertension. Irbesartan tablet h...
REVIEW ON NIOSOMES AS NOVEL DRUG DELIVERY SYSTEM
Niosomes are lamellar structures that are microscopic in size. They constitute of non-ionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. Niosomes...
DENDRIMERS AND ITS APPLICATION
A dendrimer can described as a macromolecule characterized by its highly branched 3D structure which provides a high degree of surface functionality and versatility Dendrimers also referred to as the “Polymers of the 21s...
HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF ECBOLIUM VIRIDE (FORSSK.) ALSTON ROOTS AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY
In the present study, the methanolic extract of Ecbolium viride root was evaluated for its hepatoprotective effect against CCl4 induced hepatic injury in rats. Alteration in the levels of biochemical markers of hepatic d...