Effect of Ethanolic Extract of Different Parts of Plant (Annona Squamosa) on the Fertility of Male Rats
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2017, Vol 1, Issue 5
Abstract
Plants, since ancient times, have been used globally across the civilizations as valuable, safe and natural agents of therapeutic, industrial and environmental utilities. From the inception of civilization, humans have relied on plants for their basic necessities like food, shelter, clothing, fuel and health. Of all the uses ascribed to the plants, the curative abilities of plants play an inevitable part as plants sometimes comprise sole source for healing ailments for some civilizations. Plants have also been explored for population control (Annona squamosa) is reported to posses various medicinal effects like insecticidal, antiovulatory and abortifacient. The present study therefore reports the effect of ethanolic effect of leaves, bark and seeds on the fructose level in testis, vas deferens and seminal vesicles, sperm count and sperm motility in rats. A significant decrease (p<0.05) was observed in the level of fructose in testis, vas deferens and seminal vesicle on exposure to the ethanolic extract of leaves, bark and seeds of plant (Annona squamosa) and a significant (p<0.05) decrease in sperm count and motility was also observed in the rats exposed to the extracts of plant in comparison to control rats. The decrease in fructose level, sperm count and motility was found to be time and dose dependent. Among the different parts of the plant, leaves, bark and seeds the effects were in the order leaf < bark< seed. The study clearly indicates plant extracts have potential to inhibit male fertility. For centuries, since the arousal of civilization medicinal plants have been used as valuable medicines to cure various ailments of both human and animals. Our ancient literature of Ayurvedic, Siddha, Unani and Chinese medicine provides us a lot of information about the usage of plants to fight diseases. Eighty percent population in the developing countries relies on traditional medicines that use plants for their primary health care. De Lazlo and Hanshaw initiated the interest of the use of plants to induce infertility by describing plant material used by primitive people to affect fertility [1]. Kirtikar and Basu in 1918 and in 1933 compiled the work done on the Indian medicinal plants. Indian Council of Medical Research, New Delhi in the year 1976 and 1987 published two volumes on medicinal plants [2-4]. The most important concern in India is over population that needs to be addressed and tackled. The solution to this problem is population control. Various methods are being used to control the increase in population. There are a number of methods available that are in use for female contraception while for male contraception only the barrier method and vasectomy are available. Thus, there is a need to develop multiple male contraceptive methods. The risk in the usage of the drugs has triggered the need to develop newer products from medicinal plants. The World Health Organization has set up a task force on plant research for fertility regulation with an objective to find new orally active non steroidal contraceptive. Since, then several commonly used plants have been reported to adversely affect male reproductive functions in wildlife and humans. Local surveys of medicinal plants in our region lead us to exploration of pharmacological properties of plant (Annona squamosa).
Authors and Affiliations
Veena B Kushwaha, Preeti Singh
Keywords
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- EP ID EP572956
- DOI 10.26717/BJSTR.2017.01.000429
- Views 177
- Downloads 0
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