Effect of ethanolic seed extract of Caesalpinia bonducella on female reproductive system of albino rat: a focus on antifertility efficacy
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: To evaluate the effect of oral administration of the ethanolic seed extract of Caesalpinia bonducella on the reproductive system in Wistar female albino rat. Methods: The study was divided into four groups. The group I received distilled water and served as vehicle treated control. Groups II, III and IV were orally administered 100, 200 and 300 mg/kg body weight dose of seed extract respectively, for 10 consecutive days and subsequently euthanized twenty four hours after the last dose. Results: The treatment prolonged the length of estrous cycle with significant increase in the duration of diestrus stage. The analysis of the principal hormones viz. LH, FSH, estradiol and progesterone showed significantly decreased levels in dose-dependant manner. Ovarian and uterine weight was significantly reduced as compared to that of the control group. Histoarchitectural observations revealed follicular atresia and degeneration of corpora lutea in ovary. Oviduct showed degeneration of mucosal folds and epithelium cells. Uterus showed evidence of degeneration of endometrial epithelium and endometrial glands. Lamina propria and muscularis layer of vagina were found slightly disorganized. Conclusions: It can be concluded that significant decrease in the hormone levels, reproductive organs weight and alterations in histoarchitecture of reproductive organs might be due to antiestrogenic nature of seed extract.
Repellent activity of herbal essential oils against Aedes aegypti (Linn.) and Culex quinquefasciatus (Say.)
Objective: To determine the mosquito repellent activity of herbal essential oils against female Aedes aegypti and Culex quinquefasciatus. Methods: On a volunteer’s forearm, 0.1 mL of each essential oil was applied to 3 c...
First report of occurrence of Triatoma williami Galv ão, Souza e Lima, 1965 naturally infected with Trypanosoma cruzi Chagas, 1909 in the State of Mato Grosso, Brazil
Objective: To identify and report the occurrence of Trypanosoma cruzi (T. cruzi) in naturally infected Triatoma williami (T. williami) (Hemiptera, Reduviidae, Triatominae) in the state of Mato Grosso, Brazil. Methods: Th...
Cercarial shedding of trematodes and their associated snail intermediate hosts in Borno State, Nigeria
Objective: To determine the distribution of cercariae of trematodes and their associated snail intermediate hosts in Borno State, Nigeria. Methods: Handpicking and scooping by the aid of scoop nets were used to collect a...
Hospitalized pediatric antituberculosis drug induced hepatotoxicity: Experience of an Indonesian referral hospital
Objective: To determine the characteristics and risk factors of pediatric antituberculosis drug induced hepatotoxicity (ADIH) in Dr. Hasan Sadikin Hospital, a referral hospital in West Java, Indonesia. Methods: Medical r...
Prevalence of Helicobacter pylori infection among patients referred for endoscopy: Gender and ethnic differences in Kedah, Malaysia
Objective: To study the prevalence of Helicobacter pylori (H. pylori) infection, according to ethnicity and gender among the people of Sungai Petani, Kedah, Malaysia who undergo endoscopy. Methods: To study the epidemiol...