Effect of ethanolic seed extract of Caesalpinia bonducella on female reproductive system of albino rat: a focus on antifertility efficacy
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: To evaluate the effect of oral administration of the ethanolic seed extract of Caesalpinia bonducella on the reproductive system in Wistar female albino rat. Methods: The study was divided into four groups. The group I received distilled water and served as vehicle treated control. Groups II, III and IV were orally administered 100, 200 and 300 mg/kg body weight dose of seed extract respectively, for 10 consecutive days and subsequently euthanized twenty four hours after the last dose. Results: The treatment prolonged the length of estrous cycle with significant increase in the duration of diestrus stage. The analysis of the principal hormones viz. LH, FSH, estradiol and progesterone showed significantly decreased levels in dose-dependant manner. Ovarian and uterine weight was significantly reduced as compared to that of the control group. Histoarchitectural observations revealed follicular atresia and degeneration of corpora lutea in ovary. Oviduct showed degeneration of mucosal folds and epithelium cells. Uterus showed evidence of degeneration of endometrial epithelium and endometrial glands. Lamina propria and muscularis layer of vagina were found slightly disorganized. Conclusions: It can be concluded that significant decrease in the hormone levels, reproductive organs weight and alterations in histoarchitecture of reproductive organs might be due to antiestrogenic nature of seed extract.
Zoonotic tick-borne bacteria among wild boars (Sus scrofa) in Central Italy
The objective of this investigation was to estimate the occurrence of infections by the three zoonotic bacteria Anaplasma phagocytophilum (A. phagocytophilum), Borrelia burgdorferi sensu lato (B. burgdorferi s.l.) and Co...
Prevalence and risk factors of intestinal parasitic infections among hill tribe schoolchildren, Northern Thailand
Objective: To study the prevalence and risk factors of intestinal parasitic infections among hill tribe schoolchildren who attended 10 border patrol police schools in 2012, Chiang Rai, Thailand. Methods: A total of 339 s...
Correlation between arsenic intoxication and cognitive ability of primary school children of West Bengal
no
Pharmacological activities and medicinal properties of endemic Moroccan medicinal plant Origanum compactum (Benth) and their main compounds
Oregano [Origanum compactum Benth. (O. compactum), Lamiaceae] is an endemic Moroccan medicinal herb. It is used traditionally to fight against several disorders such as diarrhea, urolithiasis, hypertension, diabetes, and...
Seroprevalence of syphilis in a tertiary care hospital
Objective: To determine the prevalence of syphilis in a tertiary care hospital situated in Hisar, Haryana. Methods: The study is a five year study (Jan 2006 to Dec 2010), in which a total of 1550 sera obtained from clini...