Effect of Exhaustive Exercise on Liver Regeneration in an Experimental Partial Hepatectomy Model
Journal Title: Journal of Ankara University Faculty of Medicine - Year 2021, Vol 74, Issue 1
Abstract
Objectives: To investigate the results of exhaustive exercise on hepatocyte hyperplasia in an animal experiment consisting of partial hepatectomy. Materials and Methods: The experimental study was conducted with 24 Wistar Albino rats weighing between 225 and 275. Whereas exhaustive exercise was performed twice after 70% hepatectomy in the experimental group (n=12); the control group (n=12) did not perform an exercise. Then, rats underwent total hepatectomy 72 hours after partial hepatectomy. Groups were compared in terms of regeneration index, regenerative changes in hepatocytes, mitosis, and Ki-67 staining levels. Results: The groups were similar at baseline (at the time of 70% liver resection) regarding regenerative changes, mitosis count, and Ki-67. Regeneration index after exercise were 2.02±0.40 in the experimental group; and 2.42±0.21 in the control group (p=0.007). There was no difference between the groups in terms of regenerative scores (p=0.842) and Ki-67 staining (p=0.200) measured after total hepatectomy. However, mitosis was lower in the experimental group than the control group (11.5 vs. 26.0; p=0.010). Conclusion: It was showed that effect of exhaustive exercise on liver regeneration is negative according to mitosis count and liver mass increase but did not affect histologic changes of regeneration and Ki-67 staining. Blood tests and detailed immunohistochemical studies may reveal mechanisms of effect of exercise on liver cell hyperplasia and its potential clinical benefits.
Authors and Affiliations
Elvan Onur Kırımker, Süleyman Utku Çelik, Seyit Mehmet Sadık Ersöz, Mehmet Kaan Karayalçın
Keywords
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- DOI 10.4274/atfm.galenos.2020.53824
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