EFFECT OF FORMULATION AND PROCESS VARIABLES ON DRUG CONTENT AND ENTRAPMENT EFFICIENCY OF ACECLOFENAC NANOSUSPENSION
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
The present investigation was undertaken to study the effect of polymer and surfactant concentration (formulation variables) and sonication time / agitation speed (process variables) on drug content and entrapment efficiency of nanosuspension of a water insoluble drug aceclofenac. To perform this task, nanosuspension of aceclofenac for oral route were prepared by o/w emulsion method using eudragit L100 as polymer and tween 80 as surfactant in different concentrations at various sonication time and agitation speed. The prepared nanosuspensions of aceclofenac were analyzed for the drug content, entrapment efficiency and other evaluation parameters. The observed results strongly indicated that the effect of formulation and process variables were found to have significant effect on drug content and entrapment efficiency of aceclofenac nanosuspension. From the results of all 27 trials the formulations F-14BYM, F-15BYH, F-23CYM and F-24CYH exhibited optimum characters.
Authors and Affiliations
K. Masilamani, V. Ravichandiran
Keywords
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