Effect of Garlic (Allium sativum L.) Bulb Skin Extract on Urea and Creatinine Levels in Alloxan-Induced Hyperglycemia Wistar Rat
Journal Title: SAINS MEDIKA (Journal of Medicine and Health) - Year 2016, Vol 7, Issue 1
Abstract
Background: Garlic bulb skin extract contains flavonoid, alkaloid, saponin, quinone and polyphenol. Garlic bulb skin is a waste of garlic bulb which has not been optimally used so far for medical purpose. Objective: to discover the influence of garlic (Allium sativum L.) bulb skin extract on urea and creatinine levels in alloxan-induced hyperglycemia wistar rat. Methods: Experimental research using post-test control group design and its statistic analysis using Kruskal Wallis followed with Mann Witney test. The hyperglychemia rat is made by inducing alloxan at a single dose of 160 mg/kg bodyweight (BW) intraperitoneally. The garlic bulb skin extract doses used are 200mg/200gBW, 400mg/200gBW, and 800mg/200gBW for 14 days. The blood is sampled through vena orbitalis which is tested for its urea and creatinine levels. Results: The urea test in hyperglychemia rat administered with 200mg/200gBB garlic bulb skin extract (average urea level 88.87 mg/dL) has no differencce from the negative group (p>0.05), while the 400mg/200gBB and 800mg/200gBB doses (average urea levels 41.86 mg/dL and 41.96 mg/dL) show significant difference (p<0.05). The creatinine test shows significant influence (p<0.05) in extract dose of 400mg/200gBB (average creatinine level 1.16 mg/dL). Conclusion: it can be concluded that garlic bulb skin extract may have some influence in reducing urea level at 400mg/200gBB and 800mg/200gBB doses and creatinine level at 400mg/200gBB dose.
Authors and Affiliations
Abdur Rosyid
Keywords
Related Articles
- EP ID EP216951
- DOI -
- Views 94
- Downloads 0
Diagnostic Value of Direct Antibiotic Susceptibility Test for Faster Bacterial Susceptibility Reporting in Bacteremia
sepsis management. Blood culture is the gold standard for bacteraemia diagnosis. Standard antibiotic susceptibility testing needs at least three days for completion while direct method can give the result a day earlier....
Relationship between Risk Factors and Drug Use among Female Prisoners in Semarang Prison between 2012 and 2013
Drugs abuse is a complex problem facing family and society. Drug abuse cases have long long been recognized. in Indoneisia the cases started to gain public attention in 1969. Today, the similiar cases are increasing in n...
Pattern and Frequency of Skin Malignancies at Laboratory of Pathology Anatomy Dr. Kariadi General Hospital in 2008-2009
Introduction: A periodical database is important including for skin cancer. Periodical registration is needed to acknowledge changes in pattern and frequencies of skin lesion. Objective: The purpose of this study was to...
The Effect of Tempeh on the Ability of Macrophage Phagocytosis An experimental study in male Balb/c mice
Background: Consuming tempeh regularly increases the levels of isoflavones in the our body influencing the IFNγ and macrophage activating factor (MAF) that lead to the in increase in the ability of macrophage phagocytosi...
Infective Endocarditis in 60 Years Old Man at Dr. Kariadi Hospital
Infective endocarditis is an infection of the lining of the heart, particularly the cusps of valves characterized by fever and heart murmur, with or without malaise and fatigue. Clinical features can be divided into earl...