Effect of Garlic Extract (Allium sativum) on Lipid Profile of Wister Rats
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 3
Abstract
Lipid profile in Wister rats was investigated after administration of different concentration of aqueous extract of Allium sativum. The animals were divided into five (5) groups of five rats in each group, and were given different concentrations of the extract for three weeks. Thereafter, plasma lipid profiles were assayed. The result of comparing the mean total cholesterol (T. CHOL), triglyceride (TG), Low density lipoprotein (LDL) and control levels with those of the test groups A, B, C and D showed great decrease except in group D where there was an increase in mean LDL. The decrease in mean T.CHOL in group A and C were significant while decrease in T.CHOL in group B and D were not significant when compared with T.CHOL of Control samples at p< 0.05. The decrease in TG was significant in all test groups when compared with Control TG samples at p< 0.05, while the decrease in LDL in group D was not significant when compared with the LDL control samples at p< 0.05. The mean HDL of the test group showed a great increase when compared with the mean Control and the increase observed was significant when compared with the Control HDL at p< 0.05. The findings reveal that garlic bulb extract causes a significant reduction in some lipid profile parameters (p< 0.05) especially TG and an increase in HDL. These findings therefore suggest that the administration of Allium sativum extract could prevent plasma lipid related disease especially those associated with cardiovascular disease and atherosclerosis.
Authors and Affiliations
Obisike, Uchechukwu Achor
A Clinico - Sonological and Pathological Study of Gall Bladder Diseases
Background: The type of study was observational prospective in nature. Adults of both sexes who were referred for abdominal USG with a clinical diagnosis of gall bladder pathology were included in the study. A total of 5...
Interventional Modalities for Chronic Pain Management
Pain has been defined variously by varied authors. In present scenario, clinicians have realised that pain has psychological, social and cultural components, thus making it a biopsychosocial phenomenon. This calls for it...
Perioperative Morbidity of Endometrial Cancer: A Main Research Article
Purpose of the study: This study was undertaken to evaluate the perioperative morbidity in women undergoing surgery for carcinoma endometrium in a tertiary hospital in South India for a period of 5 years (2007-2012). Des...
A Review on Venetoclax – An Antineoplastic Agent
This review will focus on the drug information of Venetoclax, a small molecule oral drug that treats chronic lymphocytic leukemia (CLL) in those with a specific chromosomal abnormality, in adults with 17p deletion. Vencl...
Schwannoma of the Suprascapular Nerve Presenting With Atypical Neuralgia
The suprascapular nerve, being a mixed peripheral, supplies the supraspinatus and the infraspinatus muscles and posterior aspect of the capsule of the shoulder joint. Impairment of this nerve, therefore presents as weakn...